UniProt Accession

 GEMI6_HUMAN; Q8WXD5; B2RDP8; Q53SI5; Q8WVB4; Q9H5G6 

Genbank Protein ID

 AF453443; AK027112; AK315627; AC018693; CH471053; BC018195 

Genbank Nucleotide ID

 AAL48292.1; BAB15660.1; BAG37995.1; AAY24255.1; EAX00360.1; AAH18195.1 

Protein Name

 Gem-associated protein 6 

Protein Synonyms/Alias

 Gemin-6; SIP2 

Gene Name

 GEMIN6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
6	**MSEWMKKGPLEWQ	ubiquitination	[1]
27	VRVTASEKNEYKGWV	ubiquitination	[2]
108	ERKNSLKKWLEKNHI	ubiquitination	[3, 4]
112	SLKKWLEKNHIPITE	ubiquitination	[1, 2, 3, 4, 5]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. 

Sequence Annotation

 MOD_RES 166 166 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 167 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016604; C:nuclear body; IDA:UniProtKB.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0034660; P:ncRNA metabolic process; TAS:Reactome.
 GO:0000245; P:spliceosomal complex assembly; IEA:InterPro.
 GO:0000387; P:spliceosomal snRNP assembly; TAS:UniProtKB. 

Interpro

 IPR009422; Gemin6. 

Pfam

 PF06372; Gemin6 

SMART

  

PROSITE

  

PRINTS