UniProt Accession

 GLYAT_MOUSE; Q91XE0; Q05DG2 

Genbank Protein ID

 AK039262; AK143901; AK143803; BC010799; BC015294; BC024434 

Genbank Nucleotide ID

 BAC30297.1; BAE25590.1; BAE25544.1; AAH10799.1; AAH15294.1; AAH24434.1 

Protein Name

 Glycine N-acyltransferase 

Protein Synonyms/Alias

 Acyl-CoA:glycine N-acyltransferase; AAc; Aralkyl acyl-CoA N-acyltransferase; Aralkyl acyl-CoA:amino acid N-acyltransferase; Benzoyl-coenzyme A:glycine N-acyltransferase; Glycine N-benzoyltransferase 

Gene Name

 Glyat 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
93	SIQSFQIKHSENILY	acetylation	[1]
107	YVSSETIKKLFPSLL	acetylation	[1]
117	FPSLLDTKNLSTGSG	acetylation	[1]
125	NLSTGSGKPKAIDQD	acetylation	[1]
127	STGSGKPKAIDQDKF	acetylation	[1]
222	SQDQIMTKRGYPVYS	acetylation	[1]
233	PVYSHTEKSNIAMQK	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid (By similarity). 

Sequence Annotation

 MOD_RES 20 20 N6-acetyllysine.  

Keyword

 Acetylation; Acyltransferase; Alternative splicing; Complete proteome; Detoxification; Mitochondrion; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 296 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0047961; F:glycine N-acyltransferase activity; IEA:EC.
 GO:0047962; F:glycine N-benzoyltransferase activity; ISS:UniProtKB.
 GO:0006544; P:glycine metabolic process; ISS:UniProtKB.
 GO:0032787; P:monocarboxylic acid metabolic process; ISS:UniProtKB.
 GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR010313; Glycine_N-acyltransferase.
 IPR013652; Glycine_N-acyltransferase_C.
 IPR015938; Glycine_N-acyltransferase_N. 

Pfam

 PF08444; Gly_acyl_tr_C
 PF06021; Gly_acyl_tr_N 

SMART

  

PROSITE

  

PRINTS