UniProt Accession

 CDIPT_HUMAN; O14735; Q6FGU1; Q6ZN70 

Genbank Protein ID

 AF014807; AK131349; BT007301; CR542016; BC001444 

Genbank Nucleotide ID

 AAB94860.1; BAD18505.1; AAP35965.1; CAG46813.1; AAH01444.1 

Protein Name

 CDP-diacylglycerol--inositol 3-phosphatidyltransferase 

Protein Synonyms/Alias

 Phosphatidylinositol synthase; PI synthase; PtdIns synthase 

Gene Name

 CDIPT 

Gene Synonyms/Alias

 PIS; PIS1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
121	VRGSESHKMIDLSGN	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. 

Sequence Annotation

  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Endoplasmic reticulum; Golgi apparatus; Lipid biosynthesis; Lipid metabolism; Magnesium; Manganese; Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 213 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0043178; F:alcohol binding; IEA:Compara.
 GO:0030246; F:carbohydrate binding; IEA:Compara.
 GO:0003881; F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity; IDA:UniProtKB.
 GO:0019992; F:diacylglycerol binding; IEA:Compara.
 GO:0030145; F:manganese ion binding; IEA:Compara.
 GO:0046341; P:CDP-diacylglycerol metabolic process; IEA:Compara.
 GO:0006661; P:phosphatidylinositol biosynthetic process; IDA:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR000462; CDP-OH_P_trans.
 IPR014387; CDP_diag_ino_3_P_euk. 

Pfam

 PF01066; CDP-OH_P_transf 

SMART

  

PROSITE

 PS00379; CDP_ALCOHOL_P_TRANSF 

PRINTS