UniProt Accession

 ATPG_MOUSE; Q91VR2 

Genbank Protein ID

 BC010700 

Genbank Nucleotide ID

 AAH10700.1 

Protein Name

 ATP synthase subunit gamma, mitochondrial 

Protein Synonyms/Alias

 F-ATPase gamma subunit 

Gene Name

 Atp5c1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
79	GSLALYEKADIKAPE	acetylation	[1]
90	KAPEDKKKHLIIGVS	acetylation	[1]
115	SSVAKQMKNEVAALT	acetylation	[1]

Reference

 [1] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647] 

Functional Description

 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. 

Sequence Annotation

 MOD_RES 55 55 N6-acetyllysine (By similarity).
 MOD_RES 79 79 N6-acetyllysine.
 MOD_RES 90 90 N6-acetyllysine.
 MOD_RES 115 115 N6-acetyllysine.
 MOD_RES 146 146 Phosphoserine.
 MOD_RES 154 154 N6-acetyllysine (By similarity).
 MOD_RES 197 197 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; ATP synthesis; CF(1); Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 298 AA 

Protein Sequence

Gene Ontology

 GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; ISS:UniProtKB.
 GO:0045261; C:proton-transporting ATP synthase complex, catalytic core F(1); IEA:UniProtKB-KW.
 GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
 GO:0015986; P:ATP synthesis coupled proton transport; IEA:InterPro. 

Interpro

 IPR000131; ATPase_F1-cplx_gsu.
 IPR023632; ATPase_F1_gsu_CS.
 IPR023633; ATPase_F1_gsu_dom. 

Pfam

 PF00231; ATP-synt 

SMART

  

PROSITE

 PS00153; ATPASE_GAMMA 

PRINTS

 PR00126; ATPASEGAMMA.