CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012913
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Microtubule-associated protein RP/EB family member 2 
Protein Synonyms/Alias
  
Gene Name
 Mapre2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
155DFIQWFKKFYDANYDubiquitination[1]
164YDANYDGKEYDPVEAubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
 May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity). 
Sequence Annotation
 DOMAIN 56 158 CH.
 DOMAIN 235 305 EB1 C-terminal.
 REGION 186 326 DCTN1-binding (By similarity).
 REGION 258 301 APC-binding (By similarity).
 MOD_RES 166 166 Phosphotyrosine (By similarity).
 MOD_RES 218 218 Phosphoserine (By similarity).  
Keyword
 Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Mitosis; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 326 AA 
Protein Sequence
MPGPTQTLSP NGENNNDIIQ DNGTIIPFRK HTVRGERSYS WGMAVNVYST SITQETMSRH 60
DIIAWVNDIV SLNYTKVEQL CSGAAYCQFM DMLFPGCISL KKVKFQAKLE HEYIHNFKLL 120
QASFKRMNVD KVIPVEKLVK GRFQDNLDFI QWFKKFYDAN YDGKEYDPVE ARQGQDAIPP 180
PDPGEQIFNL PKKSHHANSP TAGAAKSSPA AKPGSTPSRP SSAKRASSSG SASRSDKDLE 240
TQVIQLNEQV HSLKLALEGV EKERDFYFGK LREIELLCQE HGQENDDLVQ RLMEVLYASD 300
EQEGQTEEPE VEEQTHDQQP QQQEEY 326 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW. 
Interpro
 IPR001715; CH-domain.
 IPR004953; EB1_C.
 IPR027328; MAPRE. 
Pfam
 PF00307; CH
 PF03271; EB1 
SMART
  
PROSITE
 PS50021; CH
 PS51230; EB1_C 
PRINTS