CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037066
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Oxysterol-binding protein 
Protein Synonyms/Alias
  
Gene Name
 OSBPL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
58SQWERTGKPFNPLLGubiquitination[1, 2, 3]
117PKLKFWGKSVEAEPRubiquitination[2, 3, 4]
269VQVIPGSKLLWRINTubiquitination[1, 2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lipid transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 370 AA 
Protein Sequence
MPIAFNEPLS FLQRITEYME HVYLIHRASC QPQPLERMQS VAAFAVSAVA SQWERTGKPF 60
NPLLGETYEL IREDLGFRFI SEQVSHHPPI SAFHSEGLNH DFLFHGSIYP KLKFWGKSVE 120
AEPRGTITLE LLKHNEAYTW TNPTCCVHNV IIGKLWIEQY GTVEILNHRT GHKCVLHFKP 180
CGLFGKELHK VEGHIQDKNK KKLFMIYGKW TECLWGIDPV SYESFKKQER RGDHLRKAKL 240
DEDSGKADSD VADDVPVAQE TVQVIPGSKL LWRINTRPPN SAQIWPARRR SGWRRSREKH 300
GGSGPRRRQS GRRGGSTQAI TPTLGPPTGC MQGITLSGIS PTAQISTEGL EGPGARDRRL 360
TRLDFLEWPL 370 
Gene Ontology
 GO:0006869; P:lipid transport; IEA:UniProtKB-KW. 
Interpro
 IPR000648; Oxysterol-bd.
 IPR018494; Oxysterol-bd_CS. 
Pfam
 PF01237; Oxysterol_BP 
SMART
  
PROSITE
 PS01013; OSBP 
PRINTS