UniProt Accession

 DNM1L_MOUSE; Q8K1M6; Q8BNQ5; Q8BQ64; Q8CGD0; Q8K1A1 

Genbank Protein ID

 AB079133; AK051443; AK080871; BC027538; BC040777; BC079635; CF914619 

Genbank Nucleotide ID

 BAC06576.1; BAC34640.1; BAC38054.1; AAH27538.1; AAH40777.1; AAH79635.1 

Protein Name

 Dynamin-1-like protein 

Protein Synonyms/Alias

 Dynamin family member proline-rich carboxyl-terminal domain less; Dymple; Dynamin-related protein 1 

Gene Name

 Dnm1l 

Gene Synonyms/Alias

 Drp1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
166	VPVGDQPKDIELQIR	ubiquitination	[1]
244	MGRVIPVKLGIIGVV	ubiquitination	[1]
311	RDCLPELKTRINVLA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis- dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. Required for programmed necrosis execution. May be involved in vesicle transport (By similarity). 

Sequence Annotation

 DOMAIN 650 741 GED.
 NP_BIND 32 39 GTP (By similarity).
 NP_BIND 152 156 GTP (By similarity).
 NP_BIND 221 224 GTP (By similarity).
 REGION 1 349 GTPase domain (By similarity).
 REGION 1 349 N-terminal dimerization domain (By
 REGION 350 495 Middle domain (By similarity).
 REGION 454 691 Interaction with GSK3B (By similarity).
 REGION 454 654 Interaction with GSK3B (By similarity).
 REGION 508 575 B domain (By similarity).
 REGION 548 742 C-terminal dimerization domain (By
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 535 535 Phosphoserine.
 MOD_RES 613 613 Phosphoserine (By similarity).
 MOD_RES 622 622 Phosphoserine; by CDK1 (By similarity).
 MOD_RES 643 643 Phosphoserine; by CAMK1 and PKA (By
 MOD_RES 650 650 S-nitrosocysteine (By similarity).
 CARBOHYD 591 591 O-linked (GlcNAc...) (By similarity).
 CARBOHYD 592 592 O-linked (GlcNAc...) (By similarity).
 CROSSLNK 538 538 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 541 541 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 564 564 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 574 574 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 600 600 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 603 603 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 612 612 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 614 614 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Golgi apparatus; GTP-binding; Hydrolase; Isopeptide bond; Membrane; Mitochondrion; Mitochondrion outer membrane; Necrosis; Nucleotide-binding; Phosphoprotein; Reference proteome; S-nitrosylation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 742 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005741; C:mitochondrial outer membrane; IDA:MGI.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0000266; P:mitochondrial fission; IMP:MGI. 

Interpro

 IPR022812; Dynamin.
 IPR000375; Dynamin_central.
 IPR001401; Dynamin_GTPase.
 IPR019762; Dynamin_GTPase_CS.
 IPR003130; GED.
 IPR020850; GTPase_effector_domain_GED.
 IPR027417; P-loop_NTPase. 

Pfam

 PF01031; Dynamin_M
 PF00350; Dynamin_N
 PF02212; GED 

SMART

 SM00053; DYNc
 SM00302; GED 

PROSITE

 PS00410; DYNAMIN
 PS51388; GED 

PRINTS

 PR00195; DYNAMIN.