CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001280
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
 AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72881.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAF72882.1; AAD03057.1; BAF85699.1; CAI21876.1; CAI21876.1; CAI21876.1; CAI21878.1; CAI21878.1; CAI21878.1; CAI22614.1; CAI22614.1; CAI22614.1; CAI22616.1; CAI22616.1; CAI22616.1; CAH70471.1; CAH70471.1; CAH70471.1; CAH70472.1; CAH70472.1; CAH70472.1; AAI01706.1; BAA25474.1 
Protein Name
 Attractin 
Protein Synonyms/Alias
 DPPT-L; Mahogany homolog 
Gene Name
 ATRN 
Gene Synonyms/Alias
 KIAA0548; MGCA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
338REEYSNLKLPRASHKubiquitination[1, 2]
749FRYENCPKDNPMYYCubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity). 
Sequence Annotation
 DOMAIN 101 129 EGF-like.
 DOMAIN 132 248 CUB.
 REPEAT 352 402 Kelch 1.
 REPEAT 404 451 Kelch 2.
 REPEAT 461 508 Kelch 3.
 REPEAT 513 564 Kelch 4.
 REPEAT 566 624 Kelch 5.
 REPEAT 625 671 Kelch 6.
 DOMAIN 703 748 PSI 1.
 DOMAIN 755 794 PSI 2.
 DOMAIN 795 919 C-type lectin.
 DOMAIN 932 983 PSI 3.
 DOMAIN 986 1061 PSI 4.
 DOMAIN 1063 1108 Laminin EGF-like 1.
 DOMAIN 1109 1157 Laminin EGF-like 2.
 CARBOHYD 213 213 N-linked (GlcNAc...) (Potential).
 CARBOHYD 237 237 N-linked (GlcNAc...) (Potential).
 CARBOHYD 242 242 N-linked (GlcNAc...) (Potential).
 CARBOHYD 253 253 N-linked (GlcNAc...) (Potential).
 CARBOHYD 264 264 N-linked (GlcNAc...).
 CARBOHYD 300 300 N-linked (GlcNAc...).
 CARBOHYD 325 325 N-linked (GlcNAc...) (Potential).
 CARBOHYD 362 362 N-linked (GlcNAc...) (Potential).
 CARBOHYD 383 383 N-linked (GlcNAc...).
 CARBOHYD 416 416 N-linked (GlcNAc...).
 CARBOHYD 428 428 N-linked (GlcNAc...).
 CARBOHYD 575 575 N-linked (GlcNAc...).
 CARBOHYD 623 623 N-linked (GlcNAc...).
 CARBOHYD 731 731 N-linked (GlcNAc...).
 CARBOHYD 863 863 N-linked (GlcNAc...) (Potential).
 CARBOHYD 914 914 N-linked (GlcNAc...) (Potential).
 CARBOHYD 923 923 N-linked (GlcNAc...) (Potential).
 CARBOHYD 986 986 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1043 1043 N-linked (GlcNAc...).
 CARBOHYD 1054 1054 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1073 1073 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1082 1082 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1198 1198 N-linked (GlcNAc...).
 CARBOHYD 1206 1206 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1250 1250 N-linked (GlcNAc...).
 CARBOHYD 1259 1259 N-linked (GlcNAc...).
 DISULFID 101 111 By similarity.
 DISULFID 105 118 By similarity.
 DISULFID 120 129 By similarity.
 DISULFID 250 260 By similarity.
 DISULFID 254 271 By similarity.
 DISULFID 273 282 By similarity.
 DISULFID 816 918 By similarity.
 DISULFID 1063 1071 By similarity.
 DISULFID 1065 1077 By similarity.
 DISULFID 1080 1089 By similarity.
 DISULFID 1092 1106 By similarity.
 DISULFID 1127 1137 By similarity.
 DISULFID 1140 1155 By similarity.  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; EGF-like domain; Glycoprotein; Inflammatory response; Kelch repeat; Laminin EGF-like domain; Lectin; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1429 AA 
Protein Sequence
MVAAAAATEA RLRRRTAATA ALAGRSGGPH WDWDVTRAGR PGLGAGLRLP RLLSPPLRPR 60
LLLLLLLLSP PLLLLLLPCE AEAAAAAAAV SGSAAAEAKE CDRPCVNGGR CNPGTGQCVC 120
PAGWVGEQCQ HCGGRFRLTG SSGFVTDGPG NYKYKTKCTW LIEGQPNRIM RLRFNHFATE 180
CSWDHLYVYD GDSIYAPLVA AFSGLIVPER DGNETVPEVV ATSGYALLHF FSDAAYNLTG 240
FNITYSFDMC PNNCSGRGEC KISNSSDTVE CECSENWKGE ACDIPHCTDN CGFPHRGICN 300
SSDVRGCSCF SDWQGPGCSV PVPANQSFWT REEYSNLKLP RASHKAVVNG NIMWVVGGYM 360
FNHSDYNMVL AYDLASREWL PLNRSVNNVV VRYGHSLALY KDKIYMYGGK IDSTGNVTNE 420
LRVFHIHNES WVLLTPKAKE QYAVVGHSAH IVTLKNGRVV MLVIFGHCPL YGYISNVQEY 480
DLDKNTWSIL HTQGALVQGG YGHSSVYDHR TRALYVHGGY KAFSANKYRL ADDLYRYDVD 540
TQMWTILKDS RFFRYLHTAV IVSGTMLVFG GNTHNDTSMS HGAKCFSSDF MAYDIACDRW 600
SVLPRPDLHH DVNRFGHSAV LHNSTMYVFG GFNSLLLSDI LVFTSEQCDA HRSEAACLAA 660
GPGIRCVWNT GSSQCISWAL ATDEQEEKLK SECFSKRTLD HDRCDQHTDC YSCTANTNDC 720
HWCNDHCVPR NHSCSEGQIS IFRYENCPKD NPMYYCNKKT SCRSCALDQN CQWEPRNQEC 780
IALPENICGI GWHLVGNSCL KITTAKENYD NAKLFCRNHN ALLASLTTQK KVEFVLKQLR 840
IMQSSQSMSK LTLTPWVGLR KINVSYWCWE DMSPFTNSLL QWMPSEPSDA GFCGILSEPS 900
TRGLKAATCI NPLNGSVCER PANHSAKQCR TPCALRTACG DCTSGSSECM WCSNMKQCVD 960
SNAYVASFPF GQCMEWYTMS TCPPENCSGY CTCSHCLEQP GCGWCTDPSN TGKGKCIEGS 1020
YKGPVKMPSQ APTGNFYPQP LLNSSMCLED SRYNWSFIHC PACQCNGHSK CINQSICEKC 1080
ENLTTGKHCE TCISGFYGDP TNGGKCQPCK CNGHASLCNT NTGKCFCTTK GVKGDECQLC 1140
EVENRYQGNP LRGTCYYTLL IDYQFTFSLS QEDDRYYTAI NFVATPDEQN RDLDMFINAS 1200
KNFNLNITWA ASFSAGTQAG EEMPVVSKTN IKEYKDSFSN EKFDFRNHPN ITFFVYVSNF 1260
TWPIKIQIAF SQHSNFMDLV QFFVTFFSCF LSLLLVAAVV WKIKQSCWAS RRREQLLREM 1320
QQMASRPFAS VNVALETDEE PPDLIGGSIK TVPKPIALEP CFGNKAAVLS VFVRLPRGLG 1380
GIPPPGQSGL AVASALVDIS QQMPIVYKEK SGAVRNRKQQ PPAQPGTCI 1429 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
 GO:0040014; P:regulation of multicellular organism growth; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IEA:Compara. 
Interpro
 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR016187; C-type_lectin_fold.
 IPR000859; CUB_dom.
 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR002049; EGF_laminin.
 IPR015915; Kelch-typ_b-propeller.
 IPR006652; Kelch_1.
 IPR003659; Plexin-like.
 IPR002165; Plexin_repeat. 
Pfam
 PF00431; CUB
 PF01344; Kelch_1
 PF01437; PSI 
SMART
 SM00034; CLECT
 SM00042; CUB
 SM00181; EGF
 SM00180; EGF_Lam
 SM00423; PSI 
PROSITE
 PS00615; C_TYPE_LECTIN_1
 PS50041; C_TYPE_LECTIN_2
 PS01180; CUB
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01248; EGF_LAM_1
 PS50027; EGF_LAM_2 
PRINTS