UniProt Accession

 PP2AB_RAT; P62716; P11082; Q6LDK0 

Genbank Protein ID

 M23591; X16044; X14087; M58438; BC085926; M58439 

Genbank Nucleotide ID

 AAA41912.1; CAA34167.1; CAA32249.1; AAA41911.1; AAH85926.1; AAA41913.1 

Protein Name

 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 

Protein Synonyms/Alias

 PP2A-beta 

Gene Name

 Ppp2cb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
36	RTLCEKAKEILTKES	acetylation	[1]
41	KAKEILTKESNVQEV	acetylation	[1]
41	KAKEILTKESNVQEV	ubiquitination	[2]
74	ELFRIGGKSPDTNYL	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. 

Sequence Annotation

 ACT_SITE 118 118 Proton donor (By similarity).
 METAL 57 57 Iron (By similarity).
 METAL 59 59 Iron (By similarity).
 METAL 85 85 Iron (By similarity).
 METAL 85 85 Manganese (By similarity).
 METAL 117 117 Manganese (By similarity).
 METAL 167 167 Manganese (By similarity).
 METAL 241 241 Manganese (By similarity).
 MOD_RES 307 307 Phosphotyrosine (By similarity).
 MOD_RES 309 309 Leucine methyl ester (By similarity).  

Keyword

 Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Hydrolase; Iron; Manganese; Metal-binding; Methylation; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 309 AA 

Protein Sequence

Gene Ontology

 GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000159; C:protein phosphatase type 2A complex; IEA:Compara.
 GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
 GO:0004722; F:protein serine/threonine phosphatase activity; IDA:RGD.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0046580; P:negative regulation of Ras protein signal transduction; IDA:RGD.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:0006470; P:protein dephosphorylation; IDA:RGD.
 GO:0010468; P:regulation of gene expression; IEA:Compara.
 GO:0046677; P:response to antibiotic; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara. 

Interpro

 IPR004843; Metallo_PEstase_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase. 

Pfam

 PF00149; Metallophos 

SMART

 SM00156; PP2Ac 

PROSITE

 PS00125; SER_THR_PHOSPHATASE 

PRINTS

 PR00114; STPHPHTASE.