UniProt Accession

 SUMF2_HUMAN; Q8NBJ7; B4DU41; B4DWQ0; Q14DW5; Q53ZE3; Q96BH2; Q9BRN3; Q9BWI1; Q9Y405 

Genbank Protein ID

 AY323911; AL050037; AY359103; AK300488; AK301627; AK075477; CH471140; BC000224; BC006159; BC015600; BC084539; BC111092 

Genbank Nucleotide ID

 AAP86218.1; CAB43247.1; AAQ89461.1; BAG62203.1; BAG63112.1; BAC11643.1; EAX07980.1; AAH00224.1; AAH06159.1; AAH15600.2; AAH84539.1; AAI11093.1 

Protein Name

 Sulfatase-modifying factor 2 

Protein Synonyms/Alias

 C-alpha-formylglycine-generating enzyme 2 

Gene Name

 SUMF2 

Gene Synonyms/Alias

 PSEC0171; UNQ1968/PRO4500 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
199	RTNLWQGKFPKGDKA	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. 

Sequence Annotation

 METAL 194 194 Calcium 1; via carbonyl oxygen.
 METAL 195 195 Calcium 1; via carbonyl oxygen.
 METAL 208 208 Calcium 1.
 METAL 210 210 Calcium 1; via carbonyl oxygen.
 METAL 229 229 Calcium 2; via carbonyl oxygen.
 METAL 232 232 Calcium 2; via carbonyl oxygen.
 METAL 234 234 Calcium 2; via carbonyl oxygen.
 METAL 236 236 Calcium 2.
 CARBOHYD 191 191 N-linked (GlcNAc...).
 DISULFID 156 290  

Keyword

 3D-structure; Alternative splicing; Calcium; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Metal-binding; Polymorphism; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 301 AA 

Protein Sequence

Gene Ontology

 GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0043687; P:post-translational protein modification; TAS:Reactome. 

Interpro

 IPR016187; C-type_lectin_fold.
 IPR005532; FGE_dom. 

Pfam

 PF03781; FGE-sulfatase 

SMART

  

PROSITE

  

PRINTS