UniProt Accession

 ANXA5_RAT; P14668 

Genbank Protein ID

 M21730; D42137 

Genbank Nucleotide ID

 AAA41512.1; BAA07708.1 

Protein Name

 Annexin A5 

Protein Synonyms/Alias

 Anchorin CII; Annexin V; Annexin-5; Calphobindin I; CBP-I; Endonexin II; Lipocortin V; Placental anticoagulant protein 4; PP4; Placental anticoagulant protein I; PAP-I; Thromboplastin inhibitor; Vascular anticoagulant-alpha; VAC-alpha 

Gene Name

 Anxa5 

Gene Synonyms/Alias

 Anx5 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
27	EVLRKAMKGLGTDED	acetylation	[1]
56	QQIAEEFKTLFGRDL	acetylation	[1]
68	RDLVNDMKSELTGKF	acetylation	[1]
74	MKSELTGKFEKLIVA	acetylation	[1]
77	ELTGKFEKLIVALMK	acetylation	[1]
84	KLIVALMKPSRLYDA	acetylation	[1]
95	LYDAYELKHALKGAG	acetylation	[1]
99	YELKHALKGAGTDEK	acetylation	[1]
106	KGAGTDEKVLTEIIA	acetylation	[1]
106	KGAGTDEKVLTEIIA	ubiquitination	[2]
191	KWGTDEEKFITILGT	acetylation	[1]
240	NLLLAVVKSIRSIPA	acetylation	[1]
258	ETLYYAMKGAGTDDH	acetylation	[1]
299	TSLYSMIKGDTSGDY	acetylation	[1]
307	GDTSGDYKKALLLLC	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. 

Sequence Annotation

 REPEAT 21 81 Annexin 1.
 REPEAT 93 153 Annexin 2.
 REPEAT 177 237 Annexin 3.
 REPEAT 252 312 Annexin 4.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 68 68 N6-acetyllysine (By similarity).
 MOD_RES 74 74 N6-acetyllysine (By similarity).
 MOD_RES 77 77 N6-acetyllysine (By similarity).
 MOD_RES 95 95 N6-acetyllysine (By similarity).
 MOD_RES 99 99 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Annexin; Blood coagulation; Calcium; Calcium/phospholipid-binding; Complete proteome; Direct protein sequencing; Hemostasis; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 319 AA 

Protein Sequence

Gene Ontology

 GO:0042995; C:cell projection; IDA:RGD.
 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0014704; C:intercalated disc; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0042383; C:sarcolemma; IDA:RGD.
 GO:0030018; C:Z disc; IDA:RGD.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IDA:RGD.
 GO:0017046; F:peptide hormone binding; IDA:RGD.
 GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
 GO:0030195; P:negative regulation of blood coagulation; IDA:RGD.
 GO:0043065; P:positive regulation of apoptotic process; IDA:RGD.
 GO:0051260; P:protein homooligomerization; IDA:RGD.
 GO:1901317; P:regulation of sperm motility; IDA:RGD.
 GO:0051592; P:response to calcium ion; IDA:RGD. 

Interpro

 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR015473; Annexins_V.
 IPR002392; AnnexinV. 

Pfam

 PF00191; Annexin 

SMART

 SM00335; ANX 

PROSITE

 PS00223; ANNEXIN 

PRINTS

 PR00196; ANNEXIN.
 PR00201; ANNEXINV.