| Tag | Content |
|---|
| CPLM ID | CPLM-014593 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Splicing factor 1 |
Protein Synonyms/Alias | CW17; Mammalian branch point-binding protein; BBP; mBBP; Transcription factor ZFM1; mZFM; Zinc finger gene in MEN1 locus; Zinc finger protein 162 |
Gene Name | Sf1 |
Gene Synonyms/Alias | Zfm1; Zfp162 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 227 | EQIRNILKQGIETPE | ubiquitination | [1] | | 306 | DPQSAQDKARMDKEY | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor (By similarity). |
Sequence Annotation | DOMAIN 141 222 KH.
ZN_FING 277 296 CCHC-type.
MOTIF 15 19 Nuclear localization signal (Potential).
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 20 20 Phosphoserine; by PKG (By similarity).
MOD_RES 80 80 Phosphoserine.
MOD_RES 82 82 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Metal-binding; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repressor; RNA-binding; Spliceosome; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 653 AA |
Protein Sequence | MATGANATPL DFPSKKRKRS RWNQDTMEQK TVIPGMPTVI PPGLTREQER AYIVQLQIED 60
LTRKLRTGDL GIPPNPEDRS PSPEPIYNSE GKRLNTREFR TRKKLEEERH TLITEMVALN 120
PDFKPPADYK PPATRVSDKV MIPQDEYPEI NFVGLLIGPR GNTLKNIEKE CNAKIMIRGK 180
GSVKEGKVGR KDGQMLPGED EPLHALVTAN TMENVKKAVE QIRNILKQGI ETPEDQNDLR 240
KMQLRELARL NGTLREDDNR ILRPWQSSET RSITNTTVCT KCGGAGHIAS DCKFQRPGDP 300
QSAQDKARMD KEYLSLMAEL GEAPVPASVG STSGPATTPL ASAPRPAAPA SNPPPPSLMS 360
TTQSRPPWMN SGPSENRPYH GMHGGGPGGP GGGPHSFPHP LPSLTGGHGG HPMQHNPNGP 420
PPPWMQPPPP PMNQGPHPPG HHGPPPMDQY LGSTPVGSGV YRLHQGKGMM PPPPMGMMPP 480
PPPPPSGQPP PPPSGPLPPW QQQQQQPPPP PPPSSSMASS TPLPWQQNTT TTTTSAGTGS 540
IPPWQQQQAA AAASPGTPQM QGNPTMVPLP PGVQPPLPPG APPPPPCSIE CLLCLLSSPN 600
SLCLSPNRAA RIPPRGSDGP SHESEDFPRP LVTLPGRQPQ QRPWWTGWFG KAA 653 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:MGI. GO:0005634; C:nucleus; ISS:MGI. GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0033327; P:Leydig cell differentiation; IGI:MGI. GO:0030238; P:male sex determination; IGI:MGI. GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. GO:0050810; P:regulation of steroid biosynthetic process; IGI:MGI. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |