| Tag | Content |
|---|
| CPLM ID | CPLM-023804 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | T-box transcription factor TBX22 |
Protein Synonyms/Alias | T-box protein 22 |
Gene Name | TBX22 |
Gene Synonyms/Alias | TBOX22 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 63 | EPLEKQPKTEPSTSA | sumoylation | [1] |
|
Reference | [1] TBX22 missense mutations found in patients with X-linked cleft palate affect DNA binding, sumoylation, and transcriptional repression. Andreou AM, Pauws E, Jones MC, Singh MK, Bussen M, Doudney K, Moore GE, Kispert A, Brosens JJ, Stanier P. Am J Hum Genet. 2007 Oct;81(4):700-12. [ PMID: 17846996] |
Functional Description | Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis. |
Sequence Annotation | DNA_BIND 96 283 T-box. |
Keyword | Alternative splicing; Complete proteome; Disease mutation; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 520 AA |
Protein Sequence | MALSSRARAF SVEALVGRPS KRKLQDPIQA EQPELREKKG GEEEEERRSS AAGKSEPLEK 60
QPKTEPSTSA SSGCGSDSGY GNSSESLEEK DIQMELQGSE LWKRFHDIGT EMIITKAGRR 120
MFPSVRVKVK GLDPGKQYHV AIDVVPVDSK RYRYVYHSSQ WMVAGNTDHL CIIPRFYVHP 180
DSPCSGETWM RQIISFDRMK LTNNEMDDKG HIILQSMHKY KPRVHVIEQG SSVDLSQIQS 240
LPTEGVKTFS FKETEFTTVT AYQNQQITKL KIERNPFAKG FRDTGRNRGV LDGLLETYPW 300
RPSFTLDFKT FGADTQSGSS GSSPVTSSGG APSPLNSLLS PLCFSPMFHL PTSSLGMPCP 360
EAYLPNVNLP LCYKICPTNF WQQQPLVLPA PERLASSNSS QSLAPLMMEV PMLSSLGVTN 420
SKSGSSEDSS DQYLQAPNST NQMLYGLQSP GNIFLPNSIT PEALSCSFHP SYDFYRYNFS 480
MPSRLISGSN HLKVNDDSQV SFGEGKCNHV HWYPAINHYL 520 |
Gene Ontology | GO:0005634; C:nucleus; NAS:UniProtKB. GO:0003677; F:DNA binding; IDA:BHF-UCL. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:UniProtKB. GO:0007275; P:multicellular organismal development; TAS:UniProtKB. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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