CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009604
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanine nucleotide-binding protein subunit beta-5 
Protein Synonyms/Alias
 Gbeta5; Transducin beta chain 5 
Gene Name
 Gnb5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
74KLEEERAKLHDVELHubiquitination[1]
96ALGQFVMKTRRTLKGubiquitination[1]
180VYPLTFDKNENMAAKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. 
Sequence Annotation
 REPEAT 103 142 WD 1.
 REPEAT 145 184 WD 2.
 REPEAT 193 234 WD 3.
 REPEAT 236 278 WD 4.
 REPEAT 279 318 WD 5.
 REPEAT 320 362 WD 6.
 REPEAT 365 394 WD 7.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Reference proteome; Repeat; Transducer; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 395 AA 
Protein Sequence
MCDQTFLVNV FGSCDKCFKQ RALRPVFKKS QQLNYCSTCA EIMATDGLHE NETLASLKSE 60
AESLKGKLEE ERAKLHDVEL HQVAERVEAL GQFVMKTRRT LKGHGNKVLC MDWCKDKRRI 120
VSSSQDGKVI VWDSFTTNKE HAVTMPCTWV MACAYAPSGC AIACGGLDNK CSVYPLTFDK 180
NENMAAKKKS VAMHTNYLSA CSFTNSDMQI LTASGDGTCA LWDVESGQLL QSFHGHGADV 240
LCLDLAPSET GNTFVSGGCD KKAMVWDMRS GQCVQAFETH ESDVNSVRYY PSGDAFASGS 300
DDATCRLYDL RADREVAIYS KESIIFGASS VDFSLSGRLL FAGYNDYTIN VWDVLKGSRV 360
SILFGHENRV STLRVSPDGT AFCSGSWDHT LRVWA 395 
Gene Ontology
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:MGI. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR001632; Gprotein_B.
 IPR016346; Guanine_nucleotide-bd_bsu.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00319; GPROTEINB.
 PR00320; GPROTEINBRPT.