CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041456
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ATP-dependent RNA helicase DDX24 
Protein Synonyms/Alias
  
Gene Name
 DDX24 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
28NPSSLFSKEAPKRKAacetylation[1]
152KADVSAWKDLFVPRPubiquitination[2, 3]
187LAPAIRDKLDILGAAubiquitination[1]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 816 AA 
Protein Sequence
MDDLVCFEEL TDYQLVSPAK NPSSLFSKEA PKRKAQAVSE EEEEEEGKSS SPKKKIKLKK 60
SKNVATEGTS TQKEFEVKDP ELEAQGDDMV CDDPEAGEMT SENLVQTAPK KKKNKGKKGL 120
EPSQSTAAKV PKKAKTWIPE VHDQKADVSA WKDLFVPRPV LRALSFLGFS APTPIQALTL 180
APAIRDKLDI LGAAETGSGK TLAFAIPMIH AVLQWQKRNA APPPSNTEAP PGETRTEAGA 240
ETRSPGKAEA ESDALPDDTV IESEALPSDI AAEARAKTGG TVSDQALLFG DDDAGEGPSS 300
LIREKPVPKQ NENEEENLDK EQTGNLKQEL DDKSATCKAY PKRPLLGLVL TPTRELAVQV 360
KQHIDAVARF TGIKTAILVG GMSTQKQQRM LNRRPEIVVA TPGRLWELIK EKHYHLRNLR 420
QLRCLVVDEA DRMVEKGHFA ELSQLLEMLN DSQYNPKRQT LVFSATLTLV HQAPARILHK 480
KHTKKMDKTA KLDLLMQKIG MRGKPKVIDL TRNEATVETL TETKIHCETD EKDFYLYYFL 540
MQYPGRSLVF ANSISCIKRL SGLLKVLDIM PLTLHACMHQ KQRLRNLEQF ARLEDCVLLA 600
TDVAARGLDI PKVQHVIHYQ VPRTSEIYVH RSGRTARATN EGLSLMLIGP EDVINFKKIY 660
KTLKKDEDIP LFPVQTKYMD VVKERIRLAR QIEKSEYRNF QACLHNSWIE QAAAALEIEL 720
EEDMYKGGKA DQQEERRRQK QMKVLKKELR HLLSQPLFTE SQKTKYPTQS GKPPLLVSAP 780
SKSESALSCL SKQKKKKTKK PKEPQPEQPQ PSTSAN 816 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000629; RNA-helicase_DEAD-box_CS.
 IPR014014; RNA_helicase_DEAD_Q_motif. 
Pfam
 PF00270; DEAD
 PF00271; Helicase_C 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 
PRINTS