CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015204
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ragulator complex protein LAMTOR1 
Protein Synonyms/Alias
 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18 
Gene Name
 Lamtor1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
20DQDQEERKLLLDPSNubiquitination[1]
31DPSNTPTKALNGAEPubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation (By similarity). 
Sequence Annotation
 REGION 121 161 Interaction with LAMTOR2 and LAMTOR3.
 MOD_RES 28 28 Phosphothreonine (By similarity).
 MOD_RES 63 63 Phosphoserine (By similarity).
 LIPID 2 2 N-myristoyl glycine (Potential).  
Keyword
 Cell membrane; Complete proteome; Direct protein sequencing; Endosome; Lipoprotein; Lysosome; Membrane; Myristate; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 161 AA 
Protein Sequence
MGCCYSSENE DSDQDQEERK LLLDPSNTPT KALNGAEPSY HSLPSARTDE QALLSSILAK 60
TASNIIDVSA ADSQGMEQHE YMDRARQYST RLAVLSSSLT HWKKLPPLPS LTSQPHQVLA 120
SEPIPFSDLQ QVSRIAAYAY SALSQIRVDA KEELVVQFGI P 161 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0071986; C:Ragulator complex; ISS:UniProtKB.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Compara.
 GO:0016049; P:cell growth; ISS:UniProtKB.
 GO:0034613; P:cellular protein localization; ISS:UniProtKB.
 GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
 GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.
 GO:0032439; P:endosome localization; ISS:UniProtKB.
 GO:0007032; P:endosome organization; ISS:UniProtKB.
 GO:0032418; P:lysosome localization; ISS:UniProtKB.
 GO:0007040; P:lysosome organization; ISS:UniProtKB.
 GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.
 GO:0032008; P:positive regulation of TOR signaling cascade; ISS:UniProtKB.
 GO:0010874; P:regulation of cholesterol efflux; ISS:UniProtKB.
 GO:0010872; P:regulation of cholesterol esterification; ISS:UniProtKB.
 GO:0060620; P:regulation of cholesterol import; ISS:UniProtKB.
 GO:0001919; P:regulation of receptor recycling; ISS:UniProtKB. 
Interpro
 IPR026310; LAMTOR1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS