CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019835
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mucolipin-1 
Protein Synonyms/Alias
 Mucolipidin 
Gene Name
 Mcoln1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
552QDSPTSGKFRRGSGSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis (By similarity). 
Sequence Annotation
 MOD_RES 10 10 Phosphoserine.
 MOD_RES 33 33 Phosphothreonine.
 MOD_RES 34 34 Phosphothreonine.
 MOD_RES 547 547 Phosphoserine.  
Keyword
 Alternative splicing; Calcium; Calcium transport; Cell membrane; Complete proteome; Endosome; Ion channel; Ion transport; Lysosome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 580 AA 
Protein Sequence
MATPAGRRAS ETERLLTPNP GYGTQVGTSP APTTPTEEED LRRRLKYFFM SPCDKFRAKG 60
RKPCKLMLQV VKILVVTVQL ILFGLSNQLV VTFREENTIA FRHLFLLGYS DGSDDTFAAY 120
TQEQLYQAIF YAVDQYLILP EISLGRYAYV RGGGGPWANG SALALCQRYY HRGHVDPAND 180
TFDIDPRVVT DCIQVDPPDR PPDIPSEDLD FLDGSASYKN LTLKFHKLIN VTIHFQLKTI 240
NLQSLINNEI PDCYTFSILI TFDNKAHSGR IPIRLETKTH IQECKHPSVS RHGDNSFRLL 300
FDVVVILTCS LSFLLCARSL LRGFLLQNEF VVFMWRRRGR EISLWERLEF VNGWYILLVT 360
SDVLTISGTV MKIGIEAKNL ASYDVCSILL GTSTLLVWVG VIRYLTFFHK YNILIATLRV 420
ALPSVMRFCC CVAVIYLGYC FCGWIVLGPY HVKFRSLSMV SECLFSLING DDMFVTFAAM 480
QAQQGHSSLV WLFSQLYLYS FISLFIYMVL SLFIALITGA YDTIKHPGGT GTEKSELQAY 540
IEQCQDSPTS GKFRRGSGSA CSLFCCCGRD SPEDHSLLVN 580 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005770; C:late endosome; ISA:MGI.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; ISA:MGI.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005261; F:cation channel activity; ISA:MGI.
 GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
 GO:0016197; P:endosomal transport; ISA:MGI. 
Interpro
 IPR013122; PKD1_2_channel. 
Pfam
 PF08016; PKD_channel 
SMART
  
PROSITE
  
PRINTS