UniProt Accession

 SERC_MOUSE; Q99K85 

Genbank Protein ID

 AF259674; BC004827 

Genbank Nucleotide ID

 AAK69389.1; AAH04827.1 

Protein Name

 Phosphoserine aminotransferase 

Protein Synonyms/Alias

 PSAT; Endometrial progesterone-induced protein; EPIP; Phosphohydroxythreonine aminotransferase 

Gene Name

 Psat1 

Gene Synonyms/Alias

 Psa; Psat 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
5	***MEATKQVVNFGP	acetylation	[1]
16	NFGPGPAKLPHSVLL	ubiquitination	[2]
27	SVLLEIQKQLLDYRG	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity). 

Sequence Annotation

 REGION 79 80 Pyridoxal phosphate binding (By
 REGION 241 242 Pyridoxal phosphate binding (By
 BINDING 45 45 L-glutamate (By similarity).
 BINDING 107 107 Pyridoxal phosphate (By similarity).
 BINDING 156 156 Pyridoxal phosphate (By similarity).
 BINDING 176 176 Pyridoxal phosphate (By similarity).
 BINDING 199 199 Pyridoxal phosphate (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 51 51 N6-acetyllysine (By similarity).
 MOD_RES 200 200 N6-(pyridoxal phosphate)lysine (By
 MOD_RES 269 269 N6-acetyllysine (By similarity).
 MOD_RES 318 318 N6-acetyllysine (By similarity).
 MOD_RES 323 323 N6-acetyllysine (By similarity).
 MOD_RES 333 333 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Amino-acid biosynthesis; Aminotransferase; Complete proteome; Direct protein sequencing; Pyridoxal phosphate; Reference proteome; Serine biosynthesis; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 370 AA 

Protein Sequence

Gene Ontology

 GO:0004648; F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity; IEA:EC.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006564; P:L-serine biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR000192; Aminotrans_V/Cys_dSase.
 IPR020578; Aminotrans_V_PyrdxlP_BS.
 IPR022278; Pser_aminoTfrase.
 IPR003248; Pser_aminoTfrase_subgr.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 

Pfam

 PF00266; Aminotran_5 

SMART

  

PROSITE

 PS00595; AA_TRANSFER_CLASS_5 

PRINTS