CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025838
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphorylase 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
312NDNFFEGKELRLKQEubiquitination[1]
543TDLSQLKKLLPLVSDubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). 
Sequence Annotation
  
Keyword
 Carbohydrate metabolism; Glycosyltransferase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 865 AA 
Protein Sequence
IPAFACAAAF LLHLFSSASA GAMAKPLTDS EKRKQISVRG LAGLGDVAEV RKSFNRHLHF 60
TLVKDRNVAT PRDYFFALAH TVRDHLVGRW IRTQQHYYER DPKRIYYLSL EFYMGRTLQN 120
TMVNLGLQNA CDEAIYQLGL DLEELEEIEE DAGLGNGGLG RLAACFLDSM ATLGLAAYGY 180
GIRYEFGIFN QKIVNGWQVE EADDWLRYGN PWEKARPEYM LPVHFYGRVE HTPDGVKWLD 240
TQVVLAMPYD TPVPGYKNNT VNTMRLWSAK APNDFKLQDF NVGDYIEAVL DRNLAENISR 300
VLYPNDNFFE GKELRLKQEY FVVASTLQDI IRRFKSSKFG CRDPVRTCFE TFPDKVAIQL 360
NDTHPALSIP ELMRILVDVE KVDWDKAWEI TKKTCAYTNH TVLPEALERW PVSMFEKLLP 420
RHLEIIYAIN QRHLDHVAAL FPGDVDRLRR MSVIEEGDCK RINMAHLCVI GSHAVNGVAR 480
IHSEIVKQSV FKDFYELEPE KFQNKTNGIT PRRWLLLCNP GLANTIVEKI GEEFLTDLSQ 540
LKKLLPLVSD EVFIRDVAKV KQENKLKFSA FLEKEYKVKI NPSSMFDVHV KRIHEYKRQL 600
LNCLHVVTLY NRIKRDPAKA FVPRTVMIGG KAAPGYHMAK LIIKLVTSIG DVVNHDPVVG 660
DRLKVIFLEN YRVSLAEKVI PAADLSQQIS TAGTEASGTG NMKFMLNGAL TIGTMDGANV 720
EMAEEAGAEN LFIFGLRVED VEALDRKGYN AREYYDHLPE LKQAVDQISS GFFSPKEPDC 780
FKDIVNMLMH HDRFKVFADY EAYMQCQAQV DQLYRNPKEW TKKVIRNIAC SGKFSSDRTI 840
TEYAREIWGV EPSDLQIPPP NIPRD 865 
Gene Ontology
 GO:0008184; F:glycogen phosphorylase activity; IEA:InterPro.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW. 
Interpro
 IPR011833; Glycg_phsphrylas.
 IPR000811; Glyco_trans_35. 
Pfam
 PF00343; Phosphorylase 
SMART
  
PROSITE
 PS00102; PHOSPHORYLASE 
PRINTS