CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040214
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Probable global transcription activator SNF2L1 
Protein Synonyms/Alias
  
Gene Name
 SMARCA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
158EVSPSYVKGGPLRDYubiquitination[1, 2]
408MQREWYTKILMKDIDubiquitination[1]
422DVLNSSGKMDKMRLLacetylation[3, 4]
437NILMQLRKCCNHPYLubiquitination[5]
618IVERAEIKLRLDSIVubiquitination[6]
641QQSNKLAKEEMLQMIubiquitination[1]
733EPPKRERKANYAVDAubiquitination[6]
793YRKTIGYKVPRNPDIubiquitination[6]
830EETEEKEKLLTQGFTubiquitination[1]
849RDFNQFIKANEKYGRubiquitination[6, 7]
923DAKIARYKAPFHQLRubiquitination[1, 6, 7]
939QYGTSKGKNYTEEEDubiquitination[7, 8]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [8] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1005 AA 
Protein Sequence
MEQDTAAVAA TVAAADATAT IVVIEDEQPG PSTSQEEKNV SSFQLKLAAK APKSEKEMDP 60
EYEEKMKADR AKRFEFLLKQ TELFAHFIQP SAQKSPTSPL NMKLGRPRIK KDEKQSLISA 120
GDYRHRRTEQ EEDEELLSES RKTSNVCIRF EVSPSYVKGG PLRDYQIRGL NWLISLYENG 180
VNGILADEMG LGKTLQTIAL LGYLKHYRNI PGPHMVLVPK STLHNWMNEF KRWVPSLRVI 240
CFVGDKDARA AFIRDEMMPG EWDVCVTSYE MVIKEKSVFK KFHWRYLVID EAHRIKNEKS 300
KLSEIVREFK STNRLLLTGT PLQNNLHELW ALLNFLLPDV FNSADDFDSW FDTKNCLGDQ 360
KLVERLHAVL KPFLLRRIKT DVEKSLPPKK EIKIYLGLSK MQREWYTKIL MKDIDVLNSS 420
GKMDKMRLLN ILMQLRKCCN HPYLFDGAEP GPPYTTDEHI VSNSGKMVVL DKLLAKLKEQ 480
GSRVLIFSQM TRLLDILEDY CMWRGYEYCR LDGQTPHEER EDKFLEVEFL GQREAIEAFN 540
APNSSKFIFM LSTRAGGLGI NLASADVVIL YDSDWNPQVD LQAMDRAHRI GQKKPVRVFR 600
LITDNTVEER IVERAEIKLR LDSIVIQQGR LIDQQSNKLA KEEMLQMIRH GATHVFASKE 660
SELTDEDITT ILERGEKKTA EMNERLQKMG ESSLRNFRMD IEQSLYKFEG EDYREKQKLG 720
MVEWIEPPKR ERKANYAVDA YFREALRVSE PKIPKAPRPP KQPNVQDFQF FPPRLFELLE 780
KEILYYRKTI GYKVPRNPDI PNPALAQREE QKKIDGAEPL TPEETEEKEK LLTQGFTNWT 840
KRDFNQFIKA NEKYGRDDID NIAREVEGKS PEEVMEYSAV FWERCNELQD IEKIMAQIER 900
GEARIQRRIS IKKALDAKIA RYKAPFHQLR IQYGTSKGKN YTEEEDRFLI CMLHKMGFDR 960
ENVYEELRQC VRNAPQFRFD WFIKSRTAME FQRRCNTLIS LIEKE 1005 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004386; F:helicase activity; IEA:InterPro.
 GO:0031491; F:nucleosome binding; IEA:InterPro.
 GO:0043044; P:ATP-dependent chromatin remodeling; IEA:InterPro. 
Interpro
 IPR020838; DBINO.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR009057; Homeodomain-like.
 IPR015194; ISWI_HAND-dom.
 IPR027417; P-loop_NTPase.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom.
 IPR015195; SLIDE.
 IPR000330; SNF2_N. 
Pfam
 PF13892; DBINO
 PF09110; HAND
 PF00271; Helicase_C
 PF09111; SLIDE
 PF00176; SNF2_N 
SMART
 SM00487; DEXDc
 SM00490; HELICc
 SM00717; SANT 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51293; SANT 
PRINTS