| Tag | Content |
|---|
| CPLM ID | CPLM-019660 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Remodeling and spacing factor 1 |
Protein Synonyms/Alias | Rsf-1; HBV pX-associated protein 8; Hepatitis B virus X-associated protein; p325 subunit of RSF chromatin-remodeling complex |
Gene Name | RSF1 |
Gene Synonyms/Alias | HBXAP; XAP8 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 184 | QIDPVLLKNSSQQDN | ubiquitination | [1] | | 327 | IEFGGNIKSSHEITE | ubiquitination | [1] | | 335 | SSHEITEKSTEETEK | ubiquitination | [1] | | 467 | NSVITSMKTGELEKE | ubiquitination | [1] | | 785 | EESTALQKTDKKEIL | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF- alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain. |
Sequence Annotation | DOMAIN 17 84 DDT.
ZN_FING 891 941 PHD-type.
MOD_RES 227 227 Phosphoserine.
MOD_RES 397 397 Phosphoserine.
MOD_RES 473 473 Phosphoserine.
MOD_RES 524 524 Phosphoserine.
MOD_RES 604 604 Phosphoserine.
MOD_RES 622 622 Phosphoserine.
MOD_RES 629 629 Phosphoserine.
MOD_RES 748 748 Phosphoserine.
MOD_RES 882 882 Phosphoserine.
MOD_RES 1050 1050 N6-acetyllysine.
MOD_RES 1096 1096 Phosphoserine.
MOD_RES 1098 1098 Phosphoserine.
MOD_RES 1105 1105 Phosphoserine.
MOD_RES 1221 1221 Phosphoserine.
MOD_RES 1223 1223 Phosphoserine.
MOD_RES 1226 1226 Phosphoserine.
MOD_RES 1258 1258 Phosphoserine.
MOD_RES 1277 1277 Phosphoserine.
MOD_RES 1278 1278 Phosphothreonine.
MOD_RES 1305 1305 Phosphothreonine.
MOD_RES 1310 1310 Phosphoserine.
MOD_RES 1325 1325 Phosphoserine.
MOD_RES 1339 1339 N6-acetyllysine.
MOD_RES 1345 1345 Phosphoserine.
MOD_RES 1359 1359 Phosphoserine.
MOD_RES 1375 1375 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Chromatin regulator; Coiled coil; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1441 AA |
Protein Sequence | MATAAAAAAV MAPPGCPGSC PNFAVVCSFL ERYGPLLDLP ELPFPELERV LQAPPPDVGN 60
GEVPKELVEL HLKLMRKIGK SVTADRWEKY LIKYLCECQF DDNLKFKNII NEEDADTMRL 120
QPIGRDKDGL MYWYQLDQDH NVRMYIEEQD DQDGSSWKCI VRNRNELAET LALLKAQIDP 180
VLLKNSSQQD NSSRESPSLE DEETKKEEET PKQEEQKESE KMKSEEQPMD LENRSTANVL 240
EETTVKKEKE DEKELVKLPV IVKLEKPLPE NEEKKIIKEE SDSFKENVKP IKVEVKECRA 300
DPKDTKSSME KPVAQEPERI EFGGNIKSSH EITEKSTEET EKLKNDQQAK IPLKKREIKL 360
SDDFDSPVKG PLCKSVTPTK EFLKDEIKQE EETCKRISTI TALGHEGKQL VNGEVSDERV 420
APNFKTEPIE TKFYETKEES YSPSKDRNII TEGNGTESLN SVITSMKTGE LEKETAPLRK 480
DADSSISVLE IHSQKAQIEE PDPPEMETSL DSSEMAKDLS SKTALSSTES CTMKGEEKSP 540
KTKKDKRPPI LECLEKLEKS KKTFLDKDAQ RLSPIPEEVP KSTLESEKPG SPEAAETSPP 600
SNIIDHCEKL ASEKEVVECQ STSTVGGQSV KKVDLETLKE DSEFTKVEMD NLDNAQTSGI 660
EEPSETKGSM QKSKFKYKLV PEEETTASEN TEITSERQKE GIKLTIRISS RKKKPDSPPK 720
VLEPENKQEK TEKEEEKTNV GRTLRRSPRI SRPTAKVAEI RDQKADKKRG EGEDEVEEES 780
TALQKTDKKE ILKKSEKDTN SKVSKVKPKG KVRWTGSRTR GRWKYSSNDE SEGSGSEKSS 840
AASEEEEEKE SEEAILADDD EPCKKCGLPN HPELILLCDS CDSGYHTACL RPPLMIIPDG 900
EWFCPPCQHK LLCEKLEEQL QDLDVALKKK ERAERRKERL VYVGISIENI IPPQEPDFSE 960
DQEEKKKDSK KSKANLLERR STRTRKCISY RFDEFDEAID EAIEDDIKEA DGGGVGRGKD 1020
ISTITGHRGK DISTILDEER KENKRPQRAA AARRKKRRRL NDLDSDSNLD EEESEDEFKI 1080
SDGSQDEFVV SDENPDESEE DPPSNDDSDT DFCSRRLRRH PSRPMRQSRR LRRKTPKKKY 1140
SDDDEEEESE ENSRDSESDF SDDFSDDFVE TRRRRSRRNQ KRQINYKEDS ESDGSQKSLR 1200
RGKEIRRVHK RRLSSSESEE SYLSKNSEDD ELAKESKRSV RKRGRSTDEY SEADEEEEEE 1260
EGKPSRKRLH RIETDEEESC DNAHGDANQP ARDSQPRVLP SEQESTKKPY RIESDEEEDF 1320
ENVGKVGSPL DYSLVDLPST NGQSPGKAIE NLIGKPTEKS QTPKDNSTAS ASLASNGTSG 1380
GQEAGAPEEE EDELLRVTDL VDYVCNSEQL 1410 |
Gene Ontology | GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0031213; C:RSF complex; IPI:UniProtKB. GO:0042393; F:histone binding; IDA:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0034080; P:CENP-A containing nucleosome assembly at centromere; TAS:Reactome. GO:0006352; P:DNA-dependent transcription, initiation; IDA:UniProtKB. GO:0043392; P:negative regulation of DNA binding; IDA:UniProtKB. GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB. GO:0016584; P:nucleosome positioning; IDA:UniProtKB. GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB. GO:0050434; P:positive regulation of viral transcription; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |