CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024667
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box only protein 31 
Protein Synonyms/Alias
  
Gene Name
 Fbxo31 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
175VGDPMRFKPLFRIHLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity). 
Sequence Annotation
 DOMAIN 50 96 F-box.
 MOD_RES 33 33 Phosphoserine (By similarity).
 MOD_RES 37 37 Phosphothreonine (By similarity).
 MOD_RES 264 264 Phosphoserine; by ATM (By similarity).  
Keyword
 Cell cycle; Complete proteome; DNA damage; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 507 AA 
Protein Sequence
MAVCARLCGV GPARGCRRRQ QRRGPAETAA ADSEADTDPE EERIEAGPAR CSLLELPPEL 60
LVEIFASLPG TDLPSLAQVC SRFRRILHTD TIWRRRCREE YGVCENLRKL EITGVSCRDV 120
YAKLLHRYRH ILGLWQPDIG PYGGLLNVVV DGLFIIGWMY LPPHDPHVGD PMRFKPLFRI 180
HLMERKSATV ECMYGHKGPH NGHIQIVKRD EFSTKCNQTD HHRMSGGRQE EFRTWLREEW 240
GRTLEDIFHE HMQELILMKF IYTSQYDNCL TYRRIYLPPS HPDDLIKPGL FKGTYGSHGL 300
EIVMLSFHGS RARGTKITGD PNIPAGQQTV EIDLQRRIQL PDVENLRNFN ELSRIVLEVR 360
EQVRQEQEAG EGPAPHREPA VKDPEGPPAK ASKEAGPGAE AAEQSSTSGQ GQPFVLPAGV 420
SSRNEDYPRT CRLCFYGTGL IAGHGFTSPE RTPGVFVLFD EDRFGFLWLE LKSFSLYSRV 480
QATFQNADAP SPQAFDEMLR NIQSLTS 507 
Gene Ontology
 GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
 GO:0008054; P:cyclin catabolic process; ISS:UniProtKB.
 GO:0031571; P:mitotic G1 DNA damage checkpoint; ISS:UniProtKB.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
 GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. 
Interpro
 IPR001810; F-box_dom_cyclin-like.
 IPR026941; FBXO31. 
Pfam
  
SMART
 SM00256; FBOX 
PROSITE
 PS50181; FBOX 
PRINTS