CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004693
UniProt Accession
Genbank Protein ID
 X52140 
Genbank Nucleotide ID
Protein Name
 Integrin alpha-1 
Protein Synonyms/Alias
 CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1; CD49a 
Gene Name
 Itga1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
765HSFYMLDKHDFQDSVacetylation[1]
1044PFGINSGKKMTISKSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. 
Sequence Annotation
 REPEAT 30 91 FG-GAP 1.
 REPEAT 101 160 FG-GAP 2.
 DOMAIN 175 364 VWFA.
 REPEAT 365 417 FG-GAP 3.
 REPEAT 422 474 FG-GAP 4.
 REPEAT 475 537 FG-GAP 5.
 REPEAT 556 614 FG-GAP 6.
 REPEAT 618 678 FG-GAP 7.
 MOTIF 1168 1172 GFFKR motif.
 CARBOHYD 100 100 N-linked (GlcNAc...) (Potential).
 CARBOHYD 105 105 N-linked (GlcNAc...) (Potential).
 CARBOHYD 112 112 N-linked (GlcNAc...) (Potential).
 CARBOHYD 217 217 N-linked (GlcNAc...) (Potential).
 CARBOHYD 317 317 N-linked (GlcNAc...) (Potential).
 CARBOHYD 341 341 N-linked (GlcNAc...) (Potential).
 CARBOHYD 402 402 N-linked (GlcNAc...) (Potential).
 CARBOHYD 418 418 N-linked (GlcNAc...) (Potential).
 CARBOHYD 459 459 N-linked (GlcNAc...) (Potential).
 CARBOHYD 531 531 N-linked (GlcNAc...) (Potential).
 CARBOHYD 698 698 N-linked (GlcNAc...) (Potential).
 CARBOHYD 747 747 N-linked (GlcNAc...) (Potential).
 CARBOHYD 779 779 N-linked (GlcNAc...) (Potential).
 CARBOHYD 820 820 N-linked (GlcNAc...) (Potential).
 CARBOHYD 839 839 N-linked (GlcNAc...) (Potential).
 CARBOHYD 882 882 N-linked (GlcNAc...) (Potential).
 CARBOHYD 907 907 N-linked (GlcNAc...) (Potential).
 CARBOHYD 938 938 N-linked (GlcNAc...) (Potential).
 CARBOHYD 965 965 N-linked (GlcNAc...) (Potential).
 CARBOHYD 973 973 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1007 1007 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1084 1084 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1103 1103 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1114 1114 N-linked (GlcNAc...) (Potential).
 DISULFID 82 92 By similarity.
 DISULFID 687 696 By similarity.
 DISULFID 702 755 By similarity.
 DISULFID 807 813 By similarity.
 DISULFID 877 885 By similarity.
 DISULFID 1029 1062 By similarity.
 DISULFID 1066 1073 By similarity.  
Keyword
 3D-structure; Calcium; Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein; Integrin; Magnesium; Membrane; Metal-binding; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1180 AA 
Protein Sequence
MVPRRPASLE VTVACIWLLT VILGFCVSFN VDVKNSMSFS GPVEDMFGYT VQQYENEEGK 60
WVLIGSPLVG QPKARTGDVY KCPVGRERAM PCVKLDLPVN TSIPNVTEIK ENMTFGSTLV 120
TNPNGGFLAC GPLYAYRCGH LHYTTGICSD VSPTFQVVNS FAPVQECSTQ LDIVIVLDGS 180
NSIYPWESVI AFLNDLLKRM DIGPKQTQVG IVQYGENVTH EFNLNKYSST EEVLVAANKI 240
GRQGGLQTMT ALGIDTARKE AFTEARGARR GVKKVMVIVT DGESHDNYRL KQVIQDCEDE 300
NIQRFSIAIL GHYNRGNLST EKFVEEIKSI ASEPTEKHFF NVSDELALVT IVKALGERIF 360
ALEATADQSA ASFEMEMSQT GFSAHYSQDW VMLGAVGAYD WNGTVVMQKA NQMVIPHNTT 420
FQTEPAKMNE PLASYLGYTV NSATIPGDVL YIAGQPRYNH TGQVVIYKME DGNINILQTL 480
GGEQIGSYFG SVLTTIDIDK DSYTDLLLVG APMYMGTEKE EQGKVYVYAV NQTRFEYQMS 540
LEPIRQTCCS SLKDNSCTKE NKNEPCGARF GTAIAAVKDL NVDGFNDVVI GAPLEDDHAG 600
AVYIYHGSGK TIREAYAQRI PSGGDGKTLK FFGQSIHGEM DLNGDGLTDV TIGGLGGAAL 660
FWARDVAVVK VTMNFEPNKV NIQKKNCRVE GKETVCINAT MCFHVKLKSK EDSIYEADLQ 720
YRVTLDSLRQ ISRSFFSGTQ ERKIQRNITV RESECIRHSF YMLDKHDFQD SVRVTLDFNL 780
TDPENGPVLD DALPNSVHEH IPFAKDCGNK ERCISDLTLN VSTTEKSLLI VKSQHDKFNV 840
SLTVKNKGDS AYNTRTVVQH SPNLIFSGIE EIQKDSCESN QNITCRVGYP FLRAGETVTF 900
KIIFQFNTSH LSENAIIHLS ATSDSEEPLE SLNDNEVNIS IPVKYEVGLQ FYSSASEHHI 960
SVAANETIPE FINSTEDIGN EINVFYTIRK RGHFPMPELQ LSISFPNLTA DGYPVLYPIG 1020
WSSSDNVNCR PRSLEDPFGI NSGKKMTISK SEVLKRGTIQ DCSSTCGVAT ITCSLLPSDL 1080
SQVNVSLLLW KPTFIRAHFS SLNLTLRGEL KSENSSLTLS SSNRKRELAI QISKDGLPGR 1140
VPLWVILLSA FAGLLLLMLL ILALWKIGFF KRPLKKKMEK 1180 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; IDA:RGD.
 GO:0045178; C:basal part of cell; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IDA:RGD.
 GO:0008305; C:integrin complex; IEA:InterPro.
 GO:0045121; C:membrane raft; IDA:RGD.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0043204; C:perikaryon; IDA:RGD.
 GO:0005518; F:collagen binding; IMP:RGD.
 GO:0005178; F:integrin binding; IMP:RGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0046982; F:protein heterodimerization activity; IMP:RGD.
 GO:0000187; P:activation of MAPK activity; IMP:RGD.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0060326; P:cell chemotaxis; IMP:RGD.
 GO:0045123; P:cellular extravasation; IEA:Compara.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
 GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; ISS:UniProtKB.
 GO:0048812; P:neuron projection morphogenesis; IMP:RGD.
 GO:0030593; P:neutrophil chemotaxis; IEA:Compara.
 GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
 GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; ISS:UniProtKB.
 GO:0042311; P:vasodilation; IMP:RGD. 
Interpro
 IPR013517; FG-GAP.
 IPR013519; Int_alpha_beta-p.
 IPR000413; Integrin_alpha.
 IPR013649; Integrin_alpha-2.
 IPR018184; Integrin_alpha_C_CS.
 IPR002035; VWF_A. 
Pfam
 PF01839; FG-GAP
 PF08441; Integrin_alpha2
 PF00092; VWA 
SMART
 SM00191; Int_alpha
 SM00327; VWA 
PROSITE
 PS51470; FG_GAP
 PS00242; INTEGRIN_ALPHA
 PS50234; VWFA 
PRINTS
 PR01185; INTEGRINA.