CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025822
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myeloid/lymphoid or mixed-lineage leukemia 2 variant 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
246LVESANEKAEREALLacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861
Functional Description
  
Sequence Annotation
  
Keyword
 Methyltransferase; Nucleus; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2704 AA 
Protein Sequence
SARFPSTPGP ELGRQALGSP LAGISTRLPG PGEPVPGPAG PAQFIELRHN VQKGLGPGGT 60
PFPGQGPPQR PRFYPVSEDP HRLAPEGLRG LAVSGLPPQK PSAPPAPELN NSLHPTPHTK 120
GPTLPTGLEL VNRPPSSTEL GRPNPLALEA GKLPCEDPEL DDDFDAHKAL EDDEELAHLG 180
LGVDVAKGDD ELGTLENLET NDPHLDDLLN GDEFDLLAYT DPELDTGDKK DIFNEHLRLV 240
ESANEKAERE ALLRGVEPGP LGPEERPPPA ADASEPRLAS VLPEVKPKVE EGGRHPSPCQ 300
FTIATPKVEP APAANSLGLG LKPGQSMMGS RDTRMGTGPF SSSGHTAEKA SFGATGGPPA 360
HLLTPSPLSG PGGSSLLEKF ELESGALTLP GGPAASGDEL DKMESSLVAS ELPLLIEDLL 420
EHEKKELQKK QQLSAQLQPA QQQQQQQQQH SLLSAPGPAQ AMSLPHEGSS PSLAGSQQQL 480
SLGLAGARQP GLPQPLMPTQ PPAHALQQRL APSMAMVSNQ GHMLSGQHGG QAGLVPQQSS 540
QPVLSQKPMG TMPPSMCMKP QQLAMQQQLA NSFFPDTDLD KFAAEDIIDP IAKAKMVALK 600
GIKKVMAQGS IGVAPGMNRQ QVSLLAQRLS GGPSSDLQNH VAAGSGQERS AGDPSQPRPN 660
PPTFAQGVIN EADQRQYEEW LFHTQQLLQM QLKVLEEQIG VHRKSRKALC AKQRTAKKAG 720
REFPEADAEK LKLVTEQQSK IQKQLDQVRK QQKEHTNLMA EYRNKQQQQQ QQQQQQQQQH 780
SAVLALSPSQ SPRLLTKLPG QLLPGHGLQP PQGPPGGQAG GLRLTPGGMA LPGQPGGPFL 840
NTALAQQQQQ QHSGGAGSLA GPSGGFFPGN LALRSLGPDS RLLQERQLQL QQQRMQLAQK 900
LQQQQQQQQQ QQHLLGQVAI QQQQQQGPGV QTNQALGPKP QGLMPPSSHQ GLLVQQLSPQ 960
PPQGPQGMLG PAQVAVLQQQ HPGALGPQGP HRQVLMTQSR VLSSPQLAQQ GQGLMGHRLV 1020
TAQQQQQQQQ HQQQGSMAGL SHLQQSLMSH SGQPKLSAQP MGSLQQLQQQ QQLQQQQQLQ 1080
QQQQQQLQQQ QQLQQQQLQQ QQQQQQLQQQ QQQQLQQQQQ QLQQQQQQQQ QQFQQQQQQQ 1140
QMGLLNQSRT LLSPQQQQQQ QVALGPGMPA KPLQHFSSPG ALGPTLLLTG KEQNTVDPAV 1200
SSEATEGPST HQGGPLAIGT TPESMATEPG EVKPSLSGDS QLLLVQPQPQ PQPSSLQLQP 1260
PLRLPGQQQQ QVSLLHTAGG GSHGQLGSGS SSEASSVPHL LAQPSVSLGD QPGSMTQNLL 1320
GPQQPMLERP MQNNTGPQPP KPGPVLQSGQ GLPGVGIMPT VGQLRAQLQG VLAKNPQLRH 1380
LSPQQQQQLQ ALLMQRQLQQ SQAVRQTPPY QEPGTQTSPL QGLLGCQPQL GGFPGPQTGP 1440
LQELGAGPRP QGPPRLPAPP GALSTGPVLG PVHPTPPPSS PQEPKRPSQL PSPSSQLPTE 1500
AQLPPTHPGT PKPQGPTLEP PPGRVSPAAA QLADTLFSKG LGPWDPPDNL AETQKPEQSS 1560
LVPGHLDQVN GQVVPEASQL SIKQEPREEP CALGAQSVKR EANGEPIGAP GTSNHLLLAG 1620
PRSEAGHLLL QKLLRAKNVQ LSTGRGSEGL RAEINGHIDS KLAGLEQKLQ GTPSNKEDAA 1680
ARKPLTPKPK RVQKASDRLV SSRKKLRKED GVRASEALLK QLKQELSLLP LTEPAITANF 1740
SLFAPFGSGC PVNGQSQLRG AFGSGALPTG PDYYSQLLTK NNLSNPPTPP SSLPPTPPPS 1800
VQQKMVNGVT PSEELGEHPK DAASARDSER ALRDTSEVKS LDLLAALPTP PHNQTEDVRM 1860
ESDEDSDSPD SIVPASSPES ILGEEAPRFP HLGSGRWEQE DRALSPVIPL IPRASIPVFP 1920
DTKPYGALGL EVPGKLPVTT WEKGKGSEVS VMLTVSAAAA KNLNGVMVAV AELLSMKIPN 1980
SYEVLFPESP ARAGTEPKKG EAEGPGGKEK GLEGKSPDTG PDWLKQFDAV LPGYTLKSQL 2040
DILSLLKQES PAPEPPTQHS YTYNVSNLDV RQLSAPPPEE PSPPPSPLAP SPASPPTEPL 2100
VELPTEPLAE PPVPSPLPLA SSPESARPKP RARPPEEGED SRPPRLKKWK GVRWKRLRLL 2160
LTIQKGSGRQ EDEREVAEFM EQLGTALRPD KVPRDMRRCC FCHEEGDGAT DGPARLLNLD 2220
LDLWVHLNCA LWSTEVYETQ GGALMNVEVA LHRGLLTKCS LCQRTGATSS CNRMRCPNVY 2280
HFACAIRAKC MFFKDKTMLC PMHKIKGPCE QELSSFAVFR RVYIERDEVK QIASIIQRGE 2340
RLHMFRVGGL VFHAIGQLLP HQMADFHSAT ALYPVGYEAT RIYWSLRTNN RRCCYRCSIG 2400
ENNGRPEFVI KVIEQGLEDL VFTDASPQAV WNRIIEPVAA MRKEADMLRL FPEYLKGEEL 2460
FGLTVHAVLR IAESLPGVES CQNYLFRYGR HPLMELPLMI NPTGCARSEP KILTHYKRPH 2520
TLNSTSMSKA YQSTFTGETN TPYSKQFVHS KSSQYRRLRT EWKNNVYLAR SRIQGLGLYA 2580
AKDLEKHTMV IEYIGTIIRN EVANRREKIY EEQNRGIYMF RINNEHVIDA TLTGGPARYI 2640
NHSCAPNCVA EVVTFDKEDK IIIISSRRIP KGEELTYDYQ FDFEDDQHKI PCHCGAWNCR 2700
KWMN 2704 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0001701; P:in utero embryonic development; IEA:Compara. 
Interpro
 IPR003889; FYrich_C.
 IPR003888; FYrich_N.
 IPR003616; Post-SET_dom.
 IPR001214; SET_dom.
 IPR001965; Znf_PHD. 
Pfam
 PF05965; FYRC
 PF05964; FYRN
 PF00856; SET 
SMART
 SM00542; FYRC
 SM00541; FYRN
 SM00249; PHD
 SM00508; PostSET
 SM00317; SET 
PROSITE
 PS51543; FYRC
 PS51542; FYRN
 PS50868; POST_SET
 PS50280; SET 
PRINTS