UniProt Accession

 MOXD1_HUMAN; Q6UVY6; Q5THU6; Q8NC97; Q8WV49; Q9H4M6; Q9Y4U3 

Genbank Protein ID

 AY007239; AY359094; AL357034; AL023578; AL357034; AL023578; AL023578; AL357034; AL023578; AL357034; CH471051; CH471051; BC018756; AK074879; AL080058 

Genbank Nucleotide ID

 AAG09636.1; AAQ89452.1; CAI15715.1; CAI15715.1; CAI15718.1; CAI15718.1; CAI19937.1; CAI19937.1; CAI19938.1; CAI19938.1; EAW48033.1; EAW48034.1; AAH18756.1; BAC11263.1; CAB45692.1 

Protein Name

 DBH-like monooxygenase protein 1 

Protein Synonyms/Alias

 Monooxygenase X 

Gene Name

 MOXD1 

Gene Synonyms/Alias

 MOX; UNQ2493/PRO5780 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
36	TLLDSEGKYWLGWSQ	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 DOMAIN 35 148 DOMON.
 ACT_SITE 203 203 Potential.
 ACT_SITE 389 389 Potential.
 METAL 235 235 Copper A (By similarity).
 METAL 236 236 Copper A (By similarity).
 METAL 307 307 Copper A (By similarity).
 METAL 389 389 Copper B (By similarity).
 METAL 391 391 Copper B (By similarity).
 METAL 464 464 Copper B (By similarity).
 CARBOHYD 114 114 N-linked (GlcNAc...) (Potential).
 CARBOHYD 247 247 N-linked (GlcNAc...) (Potential).
 CARBOHYD 476 476 N-linked (GlcNAc...) (Potential).
 CARBOHYD 517 517 N-linked (GlcNAc...) (Potential).
 DISULFID 205 257 By similarity.
 DISULFID 242 269 By similarity.
 DISULFID 364 480 By similarity.
 DISULFID 368 550 By similarity.
 DISULFID 443 465 By similarity.  

Keyword

 Alternative splicing; Complete proteome; Copper; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Membrane; Metal-binding; Monooxygenase; Oxidoreductase; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 613 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005507; F:copper ion binding; IEA:InterPro.
 GO:0004500; F:dopamine beta-monooxygenase activity; IEA:InterPro.
 GO:0006584; P:catecholamine metabolic process; IEA:InterPro. 

Interpro

 IPR014784; Cu2_ascorb_mOase-like_C.
 IPR000323; Cu2_ascorb_mOase_N.
 IPR005018; DOMON_domain.
 IPR000945; Dopamine_b_mOase.
 IPR008977; PHM/PNGase_F_dom. 

Pfam

 PF01082; Cu2_monooxygen
 PF03351; DOMON 

SMART

 SM00664; DoH 

PROSITE

 PS00084; CU2_MONOOXYGENASE_1
 PS00085; CU2_MONOOXYGENASE_2
 PS50836; DOMON 

PRINTS

 PR00767; DBMONOXGNASE.