CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004118
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uridine 5'-monophosphate synthase 
Protein Synonyms/Alias
 UMP synthase; Orotate phosphoribosyltransferase; OPRTase; Orotidine 5'-phosphate decarboxylase; OMPdecase 
Gene Name
 Umps 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
162REQGGKDKLQAQGIRacetylation[1]
223PPEKKACKELSFGARubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 REGION 2 214 OPRTase.
 REGION 215 220 Domain linker.
 REGION 221 481 OMPdecase.
 ACT_SITE 314 314 For OMPdecase activity (By similarity).
 ACT_SITE 317 317 For OMPdecase activity (By similarity).  
Keyword
 Complete proteome; Decarboxylase; Glycosyltransferase; Lyase; Multifunctional enzyme; Pyrimidine biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 481 AA 
Protein Sequence
MEVASQALGP LVTELYDVQA FKFGSFVLKS GLSSPVYIDL RGIVSRPRLL SQVADILFQT 60
AKNAGISFDS VCGVPYTALP LATVICSANH IPMLIRRKET KDYGTKRLVE GEINPGQTCL 120
VIEDVVTSGA SVLETVEVLQ KEGLKVTDAI VLLDREQGGK DKLQAQGIRL HAVCTLSQML 180
EILQQQEKID ADMVGRVKRF IQENVFSAAN HNGLPPPEKK ACKELSFGAR AELPGTHPLA 240
SKLLRLMQKK ETNLCLSADV SEARELLQLA DALGPSICML KTHVDILNDF TLDVMEELTA 300
LAKRHEFLIF EDRKFADIGN TVKKQYESGT FKIASWADIV NAHVVPGSGV VKGLQEVGLP 360
LHRACLLIAE MSSAGSLATG NYTKAAVGMA EEHCEFVIGF ISGSRVSMKP EFLHLTPGVQ 420
LETGGDHLGQ QYNSPQEVIG KRGSDVIIVG RGILAAANRL EAAEMYRKAA WEAYLSRLAV 480
Q 481 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:EC.
 GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
 GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
 GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0035690; P:cellular response to drug; IEA:Compara.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0007595; P:lactation; IEA:Compara. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR014732; OMPdecase.
 IPR018089; OMPdecase_AS.
 IPR001754; OMPdeCOase_dom.
 IPR023031; OPRT.
 IPR004467; Or_phspho_trans_dom.
 IPR000836; PRibTrfase_dom.
 IPR011060; RibuloseP-bd_barrel. 
Pfam
 PF00215; OMPdecase
 PF00156; Pribosyltran 
SMART
 SM00934; OMPdecase 
PROSITE
 PS00156; OMPDECASE
 PS00103; PUR_PYR_PR_TRANSFER 
PRINTS