CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016472
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA binding protein fox-1 homolog 3 
Protein Synonyms/Alias
 Fox-1 homolog C; Hexaribonucleotide-binding protein 3; Fox-3; Neuronal nuclei; NeuN 
Gene Name
 Rbfox3 
Gene Synonyms/Alias
 D11Bwg0517e; Hrnbp3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
182ARVMTNKKPGNPYANubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 RNA-binding protein that regulates alternative splicing events. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD). 
Sequence Annotation
 DOMAIN 99 175 RRM.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 374 AA 
Protein Sequence
MAQPYPPAQY PPPPQNGIPA EYAPPPPHPT QDYSGQTPVP PEHGMTLYTP AQTHPEQPGT 60
EASTQPIAGT QTVPQADEAA QTDNQQLHPS DPTEKQQPKR LHVSNIPFRF RDPDLRQMFG 120
QFGKILDVEI IFNERGSKGF GFVTFETSSD ADRAREKLNG TIVEGRKIEV NNATARVMTN 180
KKPGNPYANG WKLNPVVGTV YGPEFYAVTS FPYPTTGTAV AYRGAHLRGR GRAVYNTFRA 240
APPPPPIPTY GAALEQTLVK MPVPWAGLAP CPLPPQQTPE PAYPTSPAFP PLSCPFASRV 300
VYQDGFYGAE IYGGYAAYRY AQPAAATAAA YSDSYGRVYA AADPYHHTIG PTATYSIGTM 360
ASLCRGGYSR FTPY 374 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IDA:MGI.
 GO:0043484; P:regulation of RNA splicing; IEA:InterPro.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 
Interpro
 IPR025670; Fox-1_C_dom.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR017325; RNA-bd_Fox-1.
 IPR000504; RRM_dom. 
Pfam
 PF12414; Fox-1_C
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS