CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041491
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FMS-like tyrosine kinase 1, isoform CRA_a 
Protein Synonyms/Alias
 Vascular endothelial growth factor receptor 1 
Gene Name
 Flt1 
Gene Synonyms/Alias
 rCG_42658 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
540YSCKAFNKIGTVERDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1336 AA 
Protein Sequence
MVSCWDTAVL PCALLGCLLL TGYCSGSKLK GPELSLKGTQ HVMQAGQTLF LKCRGEAAHS 60
WSLPTTVSQE DKKLSVTRSA CGRNNRQFCS TLTLNMAQAN HTGLYSCRYL PKSTSKEKKM 120
ESAIYIFVSD AGSPFIEMHS DIPKLVHMTE GRELIIPCRV TSPNITVTLK KFPFDALTPD 180
GQRIAWDSRR GFIIANATYK EIGLLTCEAT VNGHLYQTSY LTHRQTNTIL DVQISPPSPV 240
RFLRGQTLVL NCTVTTDLNT RVQMSWNYPG KATKRASIRQ RIDQSNPHSN VFHSVLKINN 300
VESRDKGLYT CRVKSGSSFR TFNTSVHVYE KGFISVKHRK QQVQETIAGK RSHRLSMKVK 360
AFPSPEVVWL KDGVPATEKS ARYSVHGYSL IIKDVTAEDA GDYTILLGIK QSKLFRNLTA 420
TLIVNVKPQI YEKSVSSLPS PPLYPLGSRQ VLTCTVYGIP QPTIKWLWHP CHYNHSKERN 480
DFCFGSEESF ILDSSSNIGN RIEGITQRMM VIEGTNKTVS TLVVADSRTP GIYSCKAFNK 540
IGTVERDIRF YVTDVPNGFH VSLEKIPTEG EDLKLSCVVS KFLYRDITWI LLRTVNNRTM 600
HHSISKQKMA TTQDYSITLN LVIKNVSLED SGTYACRARN IYTGEEILRK TEVLVRDLEA 660
PLLLQNLSDH EVSISGSTTL DCQARGVPAP QITWFKNNHK IQQEPGIILG PGNSTLFIER 720
VTEEDEGVYR CRATNQKGVV ESSAYLTVQG TSDKSNLELI TLTCTCVAAT LFWLLLTLFI 780
RKLKRSSSEV KTDYLSIIMD PDEVPLDEQC ERLPYDASKW EFARERLKLG KSLGRGAFGK 840
VVQASAFGIK KSPTCRTVAV KMLKEGATAS EYKALMTELK ILTHIGHHLN VVNLLGACTK 900
QGGPLMVIVE YCKYGNLSNY LKSKRDFFCL NKDAALHMEP KKEKLEPDLE QDQKPRLDSV 960
SSSESFTSSG FQEDKSVSDV EGGEDYSEIS KQPLTMEDLI SYSFQVARGM EFLSSRKCIH 1020
RDLAARNILL SENNVVKICD FGLARDIYKN PDYVRRGDTR LPLKWMAPES IFDKVYSTKS 1080
DVWSYGVLLW EIFSLGGSPY PGVQMDEDFC SRLKEGMRMR TPEYATPEIY QIMLDCWHKD 1140
PKERPRFAEL VEKLGDLLQA NVQQDGKDYI PLNAILTRNS GFTYSVPTFS EDFFKDGFTD 1200
PKFHSGSSDD VRYVNAFKFM SLERIKTFEE LSPNATSMFE DYHLDTSSLL TSPLLKRFTW 1260
TETKPKASMK IDLRITSKSK EAGLSDLPGP SFCFSSCGHI RPVRQEDEDD PELGKESCCS 1320
PPPDYNSVVL YSSPPA 1336 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0036332; F:placental growth factor-activated receptor activity; IEA:Compara.
 GO:0036326; F:VEGF-A-activated receptor activity; IEA:Compara.
 GO:0036327; F:VEGF-B-activated receptor activity; IEA:Compara.
 GO:0048598; P:embryonic morphogenesis; IEA:Compara.
 GO:0002548; P:monocyte chemotaxis; IEA:Compara.
 GO:0001569; P:patterning of blood vessels; IEA:Compara.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0045766; P:positive regulation of angiogenesis; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0043406; P:positive regulation of MAP kinase activity; IEA:Compara.
 GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Compara.
 GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IEA:Compara.
 GO:0010863; P:positive regulation of phospholipase C activity; IEA:Compara.
 GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0002040; P:sprouting angiogenesis; IEA:Compara. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR001824; Tyr_kinase_rcpt_3_CS.
 IPR009135; Tyr_kinase_VEGFR1_rcpt_N.
 IPR009134; Tyr_kinase_VEGFR_rcpt_N. 
Pfam
 PF07679; I-set
 PF07714; Pkinase_Tyr 
SMART
 SM00409; IG
 SM00408; IGc2
 SM00219; TyrKc 
PROSITE
 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00240; RECEPTOR_TYR_KIN_III 
PRINTS
 PR01832; VEGFRECEPTOR.
 PR01833; VEGFRECEPTR1.