UniProt Accession

 PYRD_RAT; Q63707 

Genbank Protein ID

 X80778 

Genbank Nucleotide ID

 CAA56765.1 

Protein Name

 Dihydroorotate dehydrogenase (quinone), mitochondrial 

Protein Synonyms/Alias

 DHOdehase; Dihydroorotate oxidase 

Gene Name

 Dhodh 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
235	ELRHLLSKVLQERDA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. 

Sequence Annotation

 NP_BIND 95 99 FMN.
 NP_BIND 355 356 FMN.
 REGION 144 148 Substrate binding.
 REGION 211 216 Substrate binding (By similarity).
 REGION 283 284 Substrate binding.
 ACT_SITE 214 214 Nucleophile (By similarity).
 BINDING 99 99 Substrate.
 BINDING 119 119 FMN.
 BINDING 180 180 FMN.
 BINDING 211 211 FMN.
 BINDING 211 211 Substrate.
 BINDING 254 254 FMN.
 BINDING 282 282 FMN; via carbonyl oxygen.
 BINDING 305 305 FMN; via amide nitrogen.
 BINDING 334 334 FMN; via amide nitrogen.  

Keyword

 3D-structure; Complete proteome; Flavoprotein; FMN; Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Pyrimidine biosynthesis; Reference proteome; Transit peptide; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 395 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:RGD.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0004158; F:dihydroorotate oxidase activity; IDA:RGD.
 GO:0008144; F:drug binding; IPI:RGD.
 GO:0010181; F:FMN binding; IDA:RGD.
 GO:0048039; F:ubiquinone binding; IDA:RGD.
 GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IDA:RGD.
 GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0007565; P:female pregnancy; IEP:RGD.
 GO:0007595; P:lactation; IEP:RGD.
 GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
 GO:0090140; P:regulation of mitochondrial fission; IMP:RGD.
 GO:0031000; P:response to caffeine; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0042594; P:response to starvation; IEP:RGD. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR012135; Dihydroorotate_DH_1_2.
 IPR005719; Dihydroorotate_DH_2.
 IPR001295; Dihydroorotate_DH_CS. 

Pfam

 PF01180; DHO_dh 

SMART

  

PROSITE

 PS00911; DHODEHASE_1
 PS00912; DHODEHASE_2 

PRINTS