CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010880
UniProt Accession
Genbank Protein ID
 X63039 
Genbank Nucleotide ID
Protein Name
 Ras suppressor protein 1 
Protein Synonyms/Alias
 RSP-1; Rsu-1 
Gene Name
 Rsu1 
Gene Synonyms/Alias
 Rsp1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
89ISSLQKLKHLNLGMNubiquitination[1]
158PDIGKLTKLQILSLRubiquitination[1]
243YIRSETYKYLYGRHMubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro. 
Sequence Annotation
 REPEAT 41 63 LRR 1.
 REPEAT 64 85 LRR 2.
 REPEAT 87 108 LRR 3.
 REPEAT 110 133 LRR 4.
 REPEAT 135 156 LRR 5.
 REPEAT 158 179 LRR 6.
 REPEAT 181 202 LRR 7.  
Keyword
 Complete proteome; Leucine-rich repeat; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 277 AA 
Protein Sequence
MSKSLKKLVE ESREKNQPEV DMSDRGISSM LDVNGLFSLA HITQLVLSHN KLTTVPPNVA 60
ELKNLEVLNF FNNQIEELPT QISSLQKLKH LNLGMNRLNT LPRGFGSSRL LEVLELTYNN 120
LNEHSLPGNF FYLTTLRALY LSDNDFEILP PDIGKLTKLQ ILSLRDNDLI SLPKEIGELT 180
QLKELHIQGN RLTVLPPELG NLDLTGQKQV FKAENNPWVT PIADQFQLGV SHVFEYIRSE 240
TYKYLYGRHM QANPEPPKKN NDKSKKISRK PLAAKNK 277 
Gene Ontology
 GO:0007265; P:Ras protein signal transduction; IMP:MGI. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003591; Leu-rich_rpt_typical-subtyp. 
Pfam
 PF00560; LRR_1
 PF12799; LRR_4 
SMART
 SM00369; LRR_TYP 
PROSITE
 PS51450; LRR 
PRINTS