CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018092
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 483 
Protein Synonyms/Alias
 Zinc finger protein with KRAB and SCAN domains 16 
Gene Name
 ZNF483 
Gene Synonyms/Alias
 KIAA1962; ZKSCAN16 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
336SRRYNESKKPFSFHSmethylation[1]
337RRYNESKKPFSFHSDmethylation[1]
350SDLVLNRKEKTAGEKmethylation[1]
352LVLNRKEKTAGEKSRmethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 52 134 SCAN box.
 DOMAIN 170 241 KRAB.
 ZN_FING 439 461 C2H2-type 1.
 ZN_FING 467 489 C2H2-type 2.
 ZN_FING 495 517 C2H2-type 3.
 ZN_FING 523 545 C2H2-type 4.
 ZN_FING 551 573 C2H2-type 5.
 ZN_FING 579 601 C2H2-type 6.
 ZN_FING 607 629 C2H2-type 7.
 ZN_FING 635 657 C2H2-type 8.
 ZN_FING 663 685 C2H2-type 9.
 ZN_FING 691 713 C2H2-type 10.
 ZN_FING 719 741 C2H2-type 11.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 744 AA 
Protein Sequence
MQAVVPLNKM TAISPEPQTL ASTEQNEVPR VVTSGEQEAI LRGNAADAES FRQRFRWFCY 60
SEVAGPRKAL SQLWELCNQW LRPDIHTKEQ ILELLVFEQF LTILPGEIRI WVKSQHPESS 120
EEVVTLIEDL TQMLEEKDPV SQDSTVSQEE NSKEDKMVTV CPNTESCESI TLKDVAVNFS 180
RGEWKKLEPF QKELYKEVLL ENLRNLEFLD FPVSKLELIS QLKWVELPWL LEEVSKSSRL 240
DESALDKIIE RCLRDDDHGL MEESQQYCGS SEEDHGNQGN SKGRVAQNKT LGSGSRGKKF 300
DPDKSPFGHN FKETSDLIKH LRVYLRKKSR RYNESKKPFS FHSDLVLNRK EKTAGEKSRK 360
SNDGGKVLSH SSALTEHQKR QKIHLGDRSQ KCSKCGIIFI RRSTLSRRKT PMCEKCRKDS 420
CQEAALNKDE GNESGEKTHK CSKCGKAFGY SASLTKHRRI HTGEKPYMCN ECGKAFSDSS 480
SLTPHHRTHS GEKPFKCDDC GKGFTLSAHL IKHQRIHTGE KPYKCKDCGR PFSDSSSLIQ 540
HQRIHTGEKP YTCSNCGKSF SHSSSLSKHQ RIHTGEKPYK CGECGKAFRQ NSCLTRHQRI 600
HTGEKPYLCN DCGMTFSHFT SVIYHQRLHS GEKPYKCNQC EKAFPTHSLL SRHQRIHTGV 660
KPYKCKECGK SFSQSSSLNE HHRIHTGEKP YECNYCGATF SRSSILVEHL KIHTGRREYE 720
CNECEKTFKS NSGLIRHRGF HSAE 744 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0016032; P:viral reproduction; IEA:InterPro. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR008916; Retrov_capsid_C.
 IPR003309; Tscrpt_reg_SCAN.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB
 PF02023; SCAN 
SMART
 SM00349; KRAB
 SM00431; SCAN
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS50804; SCAN_BOX
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS