UniProt Accession

 SIGIR_MOUSE; Q9JLZ8; Q52L48 

Genbank Protein ID

 AF113795; BC010806; BC094069 

Genbank Nucleotide ID

 AAF26200.1; AAH10806.1; AAH94069.1 

Protein Name

 Single Ig IL-1-related receptor 

Protein Synonyms/Alias

 Single Ig IL-1R-related molecule; Single immunoglobulin domain-containing IL1R-related protein; Toll/interleukin-1 receptor 8; TIR8 

Gene Name

 Sigirr 

Gene Synonyms/Alias

 Tir8 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
178	SDCPEDRKFVNFILK	ubiquitination	[1]
185	KFVNFILKPQLERRR	ubiquitination	[1]
195	LERRRGYKLFLEDRD	ubiquitination	[1]
327	QTRLQDDKDPMLIVR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity). 

Sequence Annotation

 DOMAIN 9 108 Ig-like C2-type.
 DOMAIN 162 309 TIR.
 MOD_RES 379 379 Phosphoserine.
 CARBOHYD 31 31 N-linked (GlcNAc...) (Potential).
 CARBOHYD 58 58 N-linked (GlcNAc...) (Potential).
 CARBOHYD 73 73 N-linked (GlcNAc...) (Potential).
 CARBOHYD 85 85 N-linked (GlcNAc...) (Potential).
 CARBOHYD 101 101 N-linked (GlcNAc...) (Potential).
 DISULFID 32 97 By similarity.  

Keyword

 Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 409 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; ISS:HGNC.
 GO:0006953; P:acute-phase response; IMP:HGNC.
 GO:0045079; P:negative regulation of chemokine biosynthetic process; IMP:HGNC.
 GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IMP:HGNC.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:HGNC.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR015621; IL1-receptor_fam.
 IPR000157; TIR_dom. 

Pfam

 PF01582; TIR 

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE
 PS50104; TIR 

PRINTS