CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040354
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Valine--tRNA ligase 
Protein Synonyms/Alias
  
Gene Name
 Vars2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
198ENAEDDRKECWVVGRacetylation[1]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 581 AA 
Protein Sequence
XPDDPRYTHL HGRQLRHPLT GQLLPLITDT TVQPHVGTGA VKVTPAHSPI DAEIGTRHGL 60
TPLSVIAEDG TMTSLCGDWL QGLHRFVARE KIMCTLREQG LFRGLQEHPM VLPICSRSGD 120
VVEYLLKSQW FVRCQEMGDL AAKAVESGAL ELWPSFHQKS WQHWFAHIGD WCVSRQLWWG 180
HQIPAYRVIG ENAEDDRKEC WVVGRSEAEA RAVAAKRTGR PEAELTLERD PDVLDTWFSS 240
ALFPFSALGW PRETPDLAHF YPLTLLETGS DLLMFWVGRM VMLGTQLTGQ LPFSKVLLHS 300
MVRDRQGRKM SKSLGNVLDP RDIISGQELQ VLQAKLRDGN LDPGELAVAA AAQKKDFPYG 360
IPECGTDALR FALCSHGILG GDLHLSVSEV LNYRHFCNKL WNALRFVLRA LGDNFVPQPA 420
EEVTPSSPMD AWILSRLAFA ASECERGFLS RELSLVTHTL YHFWLHNLCD VYLEAVKPVL 480
SSVPRPPGPP QVLFSCADVG LRLLAPLMPF LAEELWQRLP PRPGGPLAPS ICVAPYPSTR 540
SLVSHGQGSG KQGGLLRAEV VTMLAVELSH GIPAQVALLA R 581 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004832; F:valine-tRNA ligase activity; IEA:InterPro.
 GO:0006450; P:regulation of translational fidelity; IEA:GOC.
 GO:0006438; P:valyl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR002300; aa-tRNA-synth_Ia.
 IPR014729; Rossmann-like_a/b/a_fold.
 IPR009080; tRNAsynth_1a_anticodon-bd.
 IPR013155; V/L/I-tRNA-synth_anticodon-bd.
 IPR009008; Val/Leu/Ile-tRNA-synth_edit.
 IPR002303; Valyl-tRNA_ligase. 
Pfam
 PF08264; Anticodon_1
 PF00133; tRNA-synt_1 
SMART
  
PROSITE
  
PRINTS
 PR00986; TRNASYNTHVAL.