| Tag | Content |
|---|
| CPLM ID | CPLM-016604 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dedicator of cytokinesis protein 1 |
Protein Synonyms/Alias | 180 kDa protein downstream of CRK; DOCK180 |
Gene Name | Dock1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 799 | RVKGAALKYLPTIVN | ubiquitination | [1] | | 1320 | QLSELLKKQAQFYEN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (By similarity). |
Sequence Annotation | DOMAIN 9 70 SH3.
DOMAIN 425 609 DHR-1.
DOMAIN 1207 1617 DHR-2.
REGION 1687 1695 Phosphoinositide-binding (Potential).
REGION 1793 1819 Interaction with NCK2 second and third
REGION 1820 1836 Interaction with NCK2 third SH3 domain
REGION 1837 1852 Interaction with NCK2 (minor) (By
MOTIF 1799 1805 SH3-binding; interaction with CRK
MOTIF 1838 1843 SH3-binding; interaction with CRK
MOD_RES 1756 1756 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Membrane; Phagocytosis; Phosphoprotein; Reference proteome; SH3 domain; SH3-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1865 AA |
Protein Sequence | MTRWVPTKRE EKYGVAFYNY DARGADELSL QIGDTVHILE TYEGWYRGYT LRKKSKKGIF 60
PASYIHLKEA IVEGKGQHET VIPGDLPLIQ EVTTTLREWS TIWRQLYVQD NREMFRSVRH 120
MIYDLIEWRS QILSGTLPQD ELKELKKKVT AKIDYGNRIL DLDLVVRDED GNILDPELTS 180
TISLFRAHEV ASKQVEERLQ EEKSQKQNMD INRQAKFAAT PSLALFVNLK NVVCKIGEDA 240
EVLMSLYDPM ESKFISENYL VRWSSSGLPK DIDRLHNLRA VFTDLGSKDL KREKISFVCQ 300
IVRVGRMELR DSNTRKLTSG LRRPFGVAVM DVTDIINGKV DDEDKQHFIP FQAVAGENDF 360
LQTVINKVIA AKEVNHKGQG LWVTLKLLPG DIHQIRKEFP HLVDRTTAVA RKTGFPEIIM 420
PGDVRNDIYV TLVQGDFDKG SKTTAKNVEV TVSVYDEDGK RLEHVIFPGA GDEAISEYKS 480
VIYYQVKQPR WFETLKVAIP IEDVNRSHLR FTFRHRSSQD SKDKSEKIFA LAFVKLMRYD 540
GTTLRDGEHD LIVYKAEAKK LEDAATYLSL PSTKGELEEK GHSATGKGMQ SLGSCTISKD 600
SFQISTLVCS TKLTQNVDLL GLLKWRSNTN LLQQNLRQLM KVDGGEVVKF LQDTLDALFN 660
IMMENSESET FDTLVFDALV FIIGLIADRK FQHFNPVLET YIKKHFSATL AYTKLTKVLR 720
TYVASAEKPG VNEQLYKAIK ALEYIFKFIV RSRVLFNQLY ENKGEADFVE SLLQLFRSIN 780
DMMSSLSELT VRVKGAALKY LPTIVNDVKL VFDPKELSKM FTEFILNVPA GLLTVQKLSC 840
LIEIVHSDLF TQHDCREILL PMMTDQLKYH LERQEELEAC CQLLSNILEV LYRKDVGPTQ 900
RHVQIIMETL LRTVNRTVIS MGRDSELIGN FVACMTAILR QMEDYHYAHL IKTFGKMRTD 960
VVDFLMETFI MFKNLIGKNV YPFDWVIMNT MQNKVFLRAI NQYADMLNKR FLDQANFELQ 1020
LWNNYFHLAV AFLTQESLQL ENFSSAKRAK ILNKYGDMRR QIGFEIRDMW YNLGQHKIKF 1080
IPEMVGPILE MTLIPETELR KATLPIFFDM MQCEFHSTRS FQMFENEIIT KLDHEVEGGR 1140
GDEQYKVLFD KILLEHCRKH KYLAKTGETF VKLVVRLMER LLDYRTIMHD ENKDNRMSCT 1200
VNVLNFYKEI EREEMYIRYL YKLCDLHKEC DNYTEAAYTL LLHAKLLKWS EDVCAAHLTQ 1260
RDGFQATTQG QLKEQLYQEI IHYFDKGKMW EEAIALGKEL AEQYETEMFD YEQLSELLKK 1320
QAQFYENIVK VIRPKPDYFA VGYYGQGFPS FLRGKVFIYR GKEYERREDF EARLLTQFPN 1380
AEKMKTTSPP GDDIKTSPGQ YIQCFTVKPK LDLPPRFHRP VSEQIVSFYR VNEVQRFEYS 1440
RPIRKGEKNP DNEFANMWIE RTIYTTAYKL PGILRWFEVK SVFMVEISPL ENAIETMQLT 1500
NDKISSMVQQ HLDDPGLPIN PLSMLLNGIV DPAVMGGFAN YEKAFFTDRY LQEHPEAHGQ 1560
IEKLKDLIAW QIPFLAEGIR IHGDKVTEAL RPFHERMEAC FKQLKEKVEK QYGVRTMPSG 1620
LDDRRGSRPR SMVRSFTMPS SSRPLSVASV SSFSSDSTPS RPGSDGFALE PLLPKKMHSR 1680
SQDKLDKDDP DKEKKDKKKE KRNSKHQEIF DKEFKPADSS LQQSEAVILS ETISPLRPQR 1740
PKSQVINVIG NERRFSVSPA SPSSQQTPPP VTPRAKLSFS IQPSLELNGM MGMDVADVPP 1800
PLPLKGNMAD YGNLMENQDM MVSPTSPPPP PPQRQQPPPL PSKTPPPPPP KTTRKQTSVD 1860
SGIVQ 1865 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0016477; P:cell migration; IDA:MGI. GO:0006909; P:phagocytosis; IEA:UniProtKB-KW. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |