UniProt Accession

 PPAL_HUMAN; P11117; E9PCI1; Q561W5; Q9BTU7 

Genbank Protein ID

 X12548; X15525; X15526; X15527; X15528; X15529; X15530; X15531; X15532; X15533; X15534; X15535; DA382854; AC018410; BC003160; BC093010 

Genbank Nucleotide ID

 CAA31064.1; CAA33542.1; CAA33542.1; CAA33542.1; CAA33542.1; CAA33542.1; CAA33542.1; CAA33542.1; CAA33542.1; CAA33542.1; CAA33542.1; CAA33542.1; AAH03160.1; AAH93010.1 

Protein Name

 Lysosomal acid phosphatase 

Protein Synonyms/Alias

 LAP 

Gene Name

 ACP2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
153	ITEDRLLKFPLGPCP	ubiquitination	[1, 2]

Reference

 [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 ACT_SITE 42 42 Nucleophile (By similarity).
 ACT_SITE 287 287 Proton donor (By similarity).
 CARBOHYD 92 92 N-linked (GlcNAc...).
 CARBOHYD 133 133 N-linked (GlcNAc...).
 CARBOHYD 167 167 N-linked (GlcNAc...).
 CARBOHYD 177 177 N-linked (GlcNAc...).
 CARBOHYD 191 191 N-linked (GlcNAc...) (Probable).
 CARBOHYD 267 267 N-linked (GlcNAc...).
 CARBOHYD 322 322 N-linked (GlcNAc...) (Probable).
 CARBOHYD 331 331 N-linked (GlcNAc...).
 DISULFID 159 370 By similarity.
 DISULFID 212 310 By similarity.
 DISULFID 345 349 By similarity.  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 423 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IDA:MGI.
 GO:0003993; F:acid phosphatase activity; TAS:ProtInc.
 GO:0007040; P:lysosome organization; IEA:Compara.
 GO:0001501; P:skeletal system development; IEA:Compara. 

Interpro

 IPR000560; His_Pase_superF_clade-2. 

Pfam

 PF00328; His_Phos_2 

SMART

  

PROSITE

 PS00616; HIS_ACID_PHOSPHAT_1
 PS00778; HIS_ACID_PHOSPHAT_2 

PRINTS