| Tag | Content |
|---|
| CPLM ID | CPLM-018639 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Influenza virus NS1A-binding protein homolog |
Protein Synonyms/Alias | NS1-BP; NS1-binding protein homolog; Kelch family protein Nd1-L; ND1-L2; Nd1-S |
Gene Name | Ivns1abp |
Gene Synonyms/Alias | Kiaa0850; Nd1; Nd1L; Nd1S; Ns1; Ns1bp |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 193 | VCLPSNGKLYTKVIN | ubiquitination | [1] | | 197 | SNGKLYTKVINWVQR | ubiquitination | [1] | | 369 | GTAEMNGKLIAAGGY | ubiquitination | [1] | | 477 | GSDPYGQKGLKNCDV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Plays a role in protecting the heart from doxorubicin-induced cardiomyopathy. Activates Erk signaling pathway when overexpressed in cultured cell lines. |
Sequence Annotation | DOMAIN 32 99 BTB.
DOMAIN 134 233 BACK.
REPEAT 369 415 Kelch 1.
REPEAT 416 463 Kelch 2.
REPEAT 465 512 Kelch 3.
REPEAT 513 559 Kelch 4.
REPEAT 561 606 Kelch 5.
REPEAT 608 642 Kelch 6.
MOD_RES 246 246 Phosphoserine (By similarity).
MOD_RES 277 277 Phosphoserine (By similarity).
MOD_RES 322 322 Phosphoserine (By similarity).
MOD_RES 336 336 Phosphoserine (By similarity).
MOD_RES 338 338 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Kelch repeat; Nucleus; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 642 AA |
Protein Sequence | MIPNGYLMFE DENFIESSVA KLNALRKSGQ FCDVRLQVCG HEMLAHRAVL ACCSPYLFEI 60
FNSDSDPHGV SHVKLDDLNP EAVEVLLNYA YTAQLKADKE LVKDVYSAAK KLKMDRVKQV 120
CGDYLLSRMD VTSCISYRNF ASCMGDSRLL NKVDAYIQEH LLQISEEEEF LKLPRLKLEV 180
MLEDNVCLPS NGKLYTKVIN WVQRSIWENG DSLEELMEEV QTLYYSADHK LLDGNPLDGQ 240
AEVFGSDDDH IQFVQKKPPR ENGHKQISGS STGCLSSPNA SMQSPKHEWK IVASEKTSNN 300
TYLCLAVLDS TFCVIFLHGR NSPQSSPTST PKLSKSLSFE MQPDELLEKP MSPMQYARSG 360
LGTAEMNGKL IAAGGYNREE CLRTVECYDP HTDHWSFLAP MRTPRARFQM AVLMGQLYVV 420
GGSNGHSDDL SCGEMYDPNI DDWTPVPELR TNRCNAGVCA LNGKLYIVGG SDPYGQKGLK 480
NCDVFDPVTK SWTSCAPLNI RRHQSAVCEL GGYLYIIGGA ESWNCLNTVE RYNPENNTWT 540
LIAPMNVARR GAGVAVLDGK LFVGGGFDGS HAISCVEMYD PTRNEWKMMG NMTSPRSNAG 600
ITTVGNTIYA VGGFDGNEFL NTVEVYNPQS NEWSPYTKIF QF 642 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |