CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015008
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alpha-tubulin N-acetyltransferase 
Protein Synonyms/Alias
 Alpha-TAT; TAT; Acetyltransferase mec-17 homolog 
Gene Name
 Atat1 
Gene Synonyms/Alias
 Mec17 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
162AIDRPSPKLLKFLNKacetylation[1]
233KRAEGDIKPYSSSDRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development (By similarity). 
Sequence Annotation
 REGION 124 137 Acetyl-CoA binding (By similarity).
 REGION 160 169 Acetyl-CoA binding (By similarity).  
Keyword
 Complete proteome; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 421 AA 
Protein Sequence
MEFPFDVDAL FPERITVLDQ HLRPPARRPG TTTPARVDLQ QQIMTIVDEL GKASAKAQHL 60
PAPITSALRM QSNRHVIYVL KDTSARPAGK GAIIGFLKVG YKKLFVLDDR EAHNEVEPLC 120
ILDFYIHESV QRHGHGRELF QYMLQKERVE PHQLAIDRPS PKLLKFLNKH YNLETTVPQV 180
NNFVIFEGFF AHQHRSPTPS LRATRHSRAA VVDPIPAAPA RKLPPKRAEG DIKPYSSSDR 240
EFLKVAVEPP WPLNRAPRRA TPPAHPPPRS SSLGNSPDRG PLRPFVPEQE LLRSLRLCPP 300
HPTARLLLAT DPGGSPAQRR RTRETPWGLV AQSCHYSRHG GFNTSFLGTG NQERKQGEQE 360
AEDRSASEDQ VLLQDGSGEE PTHTVAPRAQ APPAQSWMVG GDILNARVIR NLQERRNTRP 420
W 421 
Gene Ontology
 GO:0019799; F:tubulin N-acetyltransferase activity; IEA:HAMAP.
 GO:0071929; P:alpha-tubulin acetylation; IEA:InterPro.
 GO:0048666; P:neuron development; IEA:HAMAP.
 GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:HAMAP. 
Interpro
 IPR016181; Acyl_CoA_acyltransferase.
 IPR007965; Alpha-TAT. 
Pfam
 PF05301; Mec-17 
SMART
  
PROSITE
  
PRINTS