UniProt Accession

 ADH_SULSO; P39462; O74076 

Genbank Protein ID

 S51211; AJ010590; AE006641 

Genbank Nucleotide ID

 AAB24546.1; CAA09258.1; AAK42665.1 

Protein Name

 NAD-dependent alcohol dehydrogenase 

Protein Synonyms/Alias

  

Gene Name

 adh 

Gene Synonyms/Alias

 SSO2536 

Created Date

 July 27, 2013 

Organism

 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322  

NCBI Taxa ID

 273057 

Lysine Modification

Position	Peptide	Type	References
11	VRLVEIGKPLSLQEI	methylation	[1, 2]
213	EEAVEAAKRAGADYV	methylation	[1, 2]

Reference

 [1] Thermal stability and aggregation of sulfolobus solfataricus beta-glycosidase are dependent upon the N-epsilon-methylation of specific lysyl residues: critical role of in vivo post-translational modifications.
 Febbraio F, Andolfo A, Tanfani F, Briante R, Gentile F, Formisano S, Vaccaro C, Scirè A, Bertoli E, Pucci P, Nucci R.
 J Biol Chem. 2004 Mar 12;279(11):10185-94. [PMID: 14660666]
 [2] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 

Functional Description

  

Sequence Annotation

 METAL 38 38 Zinc 1; catalytic.
 METAL 68 68 Zinc 1; catalytic.
 METAL 98 98 Zinc 2.
 METAL 101 101 Zinc 2.
 METAL 104 104 Zinc 2.
 METAL 112 112 Zinc 2.
 METAL 154 154 Zinc 1; catalytic.
 MOD_RES 11 11 N6-methyllysine; partial.
 MOD_RES 213 213 N6-methyllysine; partial.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Metal-binding; Methylation; NAD; Oxidoreductase; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 347 AA 

Protein Sequence

Gene Ontology

 GO:0004022; F:alcohol dehydrogenase (NAD) activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 

Interpro

 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF08240; ADH_N
 PF00107; ADH_zinc_N 

SMART

  

PROSITE

 PS00059; ADH_ZINC 

PRINTS