CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037345
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 PX domain-containing protein kinase-like protein 
Protein Synonyms/Alias
  
Gene Name
 PXK 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
6**MAFMEKPPAGKVLubiquitination[1]
154WADLGPDKYLSDKDFubiquitination[2]
198LIRMFNEKGTLKDLIubiquitination[1]
202FNEKGTLKDLIYKAKubiquitination[1]
373VLLTTSEKPQFKIPTubiquitination[1]
402KRLIEEQKQIHQHRRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 482 AA 
Protein Sequence
MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTIAGLSL PLPPKKLIGN MDREFIAERQ 60
KGLQNYLNVI TTNHILSNCE LVKKFLDPNN YSANYTEIAL QQVSMFFRSE PKWEVVEPLK 120
DIGWRIRKKY FLMKIKNQPK ERLVLSWADL GPDKYLSDKD FQCLIKLLPS CLHPYIYRVT 180
FATANESSAL LIRMFNEKGT LKDLIYKAKP KDPFLKKYCN PKKIQGLELQ QIKTYGRQIL 240
EVLKFLHDKG FPYGHLHASN VMLDGDTCRL LDLENSLLGL PSFYRSYFSQ FRKINTLESV 300
DVHCFGHLLY EMTYGRPPDS VPVDSFPPAP SMAVVAVLES TLSCEACKNG MPTISRLLQM 360
PLFSDVLLTT SEKPQFKIPT KLKEALRIAK ECIEKRLIEE QKQIHQHRRL TRAQSHHGSE 420
EERKKRKILA RKKSKRSALE NSEEHSAKYS NSNNSAGSGA SSPLTSPSSP TPPSTSVEHA 480
PF 482 
Gene Ontology
 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0007154; P:cell communication; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR001683; Phox.
 IPR000719; Prot_kinase_cat_dom. 
Pfam
 PF00069; Pkinase
 PF00787; PX 
SMART
  
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS50195; PX 
PRINTS