UniProt Accession

 F6R307_MOUSE; F6R307 

Genbank Protein ID

 AC140443; AC160765 

Genbank Nucleotide ID

  

Protein Name

 Methylglutaconyl-CoA hydratase, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 Auh 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
80	FCAGADLKERAKMHS	acetylation	[1, 2, 3]
80	FCAGADLKERAKMHS	succinylation	[2]
84	ADLKERAKMHSSEVG	acetylation	[2]
84	ADLKERAKMHSSEVG	succinylation	[2]
96	EVGPFVSKIRSVIND	acetylation	[2, 3]
96	EVGPFVSKIRSVIND	succinylation	[2]
140	RVAASSAKMGLVETK	acetylation	[1, 2, 3, 4]
140	RVAASSAKMGLVETK	succinylation	[2]
140	RVAASSAKMGLVETK	succinylation	[2]
147	KMGLVETKLAIIPGG	acetylation	[1, 2, 3, 4]
147	KMGLVETKLAIIPGG	succinylation	[2]

Reference

 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 219 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004300; F:enoyl-CoA hydratase activity; IDA:MGI.
 GO:0003723; F:RNA binding; IDA:MGI.
 GO:0000288; P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; TAS:MGI. 

Interpro

 IPR001753; Crotonase_core_superfam.
 IPR018376; Enoyl-CoA_hyd/isom_CS. 

Pfam

 PF00378; ECH 

SMART

  

PROSITE

 PS00166; ENOYL_COA_HYDRATASE 

PRINTS