CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034167
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Alanine--glyoxylate aminotransferase 2, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Agxt2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
44PKLTLHTKHSMPPCDacetylation[1]
56PCDFSPEKYQSLAYSacetylation[1, 2]
70SRVLAIHKQHLSPVDacetylation[1, 2, 3]
70SRVLAIHKQHLSPVDsuccinylation[3]
83VDTAYFRKPLLLHQGacetylation[1]
127PKVSAVAKKQIDRLWacetylation[2]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Pyridoxal phosphate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 234 AA 
Protein Sequence
MSLAWRNLQK PFYLETSLRI LQMRPSLSLG ASRIAVPKLT LHTKHSMPPC DFSPEKYQSL 60
AYSRVLAIHK QHLSPVDTAY FRKPLLLHQG HMEWLFDSEG NRYLDFFSGI VTVSVGHCHP 120
KVSAVAKKQI DRLWHTSSVF FHSPMHEYAE KLSALLPEPL KVIFLVNSGS EANDLAMVMA 180
RAHSNHTDII SFRGAYHGCS PYTLGLTNVG IYKMEVPGGI GCQSVSSETL TFLQ 234 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0008483; F:transaminase activity; IEA:InterPro.
 GO:0008152; P:metabolic process; IEA:GOC. 
Interpro
 IPR005814; Aminotrans_3.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00202; Aminotran_3 
SMART
  
PROSITE
  
PRINTS