CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032362
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Membrane bound catechol-O-methyltransferase 
Protein Synonyms/Alias
  
Gene Name
 COMT 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
259EVVDGLEKAIYKGPGubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Methyltransferase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 271 AA 
Protein Sequence
MPEAPPLLLA AVLLGLVLLV VLLLLLRHWG WGLCLIGWNE FILQPIHNLL MGDTKEQRIL 60
NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV GAVIQEHQPF VLLELGAYCG 120
YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY 180
DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RRGTVLLADN VICPGAPDFL AHVRGSSCFE 240
CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P 271 
Gene Ontology
 GO:0016206; F:catechol O-methyltransferase activity; IEA:InterPro.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0006584; P:catecholamine metabolic process; IEA:InterPro.
 GO:0042135; P:neurotransmitter catabolic process; IEA:InterPro. 
Interpro
 IPR025782; Catechol_O-MeTrfase.
 IPR017128; Catechol_O-MeTrfase_euk.
 IPR002935; O-MeTrfase_3. 
Pfam
 PF01596; Methyltransf_3 
SMART
  
PROSITE
 PS51557; SAM_MT_CATECHOL 
PRINTS