CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000485
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Selenide, water dikinase 
Protein Synonyms/Alias
 Protein patufet; Selenium donor protein; Selenophosphate synthase; dSelD 
Gene Name
 SelD 
Gene Synonyms/Alias
 PTF1; ptuf; CG8553 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
47LTRFADLKGRGCKVPacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Synthesizes selenophosphate from selenide and ATP. Essential for progression of the cell cycle by controlling the synthesis of selenoproteins. Plays a role in apoptosis and consequently a role in imaginal disk patterning and growth. 
Sequence Annotation
 NP_BIND 290 296 ATP (Potential).
 ACT_SITE 51 51 Potential.  
Keyword
 ATP-binding; Cell cycle; Complete proteome; Developmental protein; Kinase; Nucleotide-binding; Reference proteome; Selenium; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 398 AA 
Protein Sequence
MSYAADVLNS AHLELHGGGD AELRRPFDPT AHDLDASFRL TRFADLKGRG CKVPQDVLSK 60
LVSALQQDYS AQDQEPQFLN VAIPRIGIGL DCSVIPLRHG GLCLVQTTDF FYPIVDDPYM 120
MGKIACANVL SDLYAMGVTD CDNMLMLLAV STKMTEKERD VVIPLIMRGF KDSALEAGTT 180
VTGGQSVVNP WCTIGGVAST ICQPNEYIVP DNAVVGDVLV LTKPLGTQVA VNAHQWIDQP 240
ERWNRIKLVV SEEDVRKAYH RAMNSMARLN RVAARLMHKY NAHGATDITG FGLLGHAQTL 300
AAHQKKDVSF VIHNLPVIAK MAAVAKACGN MFQLLQGHSA ETSGGLLICL PREQAAAYCK 360
DIEKQEGYQA WIIGIVEKGN KTARIIDKPR VIEVPAKD 398 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0008283; P:cell proliferation; IMP:FlyBase.
 GO:0006541; P:glutamine metabolic process; IMP:FlyBase.
 GO:0007444; P:imaginal disc development; IMP:FlyBase.
 GO:0007005; P:mitochondrion organization; IMP:FlyBase.
 GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IMP:FlyBase.
 GO:0022008; P:neurogenesis; IMP:FlyBase.
 GO:0008284; P:positive regulation of cell proliferation; IMP:FlyBase.
 GO:0016260; P:selenocysteine biosynthetic process; IMP:FlyBase. 
Interpro
 IPR010918; AIR_synth_C_dom.
 IPR000728; AIR_synth_N_dom.
 IPR016188; PurM_N-like.
 IPR004536; SelD. 
Pfam
 PF00586; AIRS
 PF02769; AIRS_C 
SMART
  
PROSITE
  
PRINTS