CPLM-028089

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-028089

UniProt Accession

Q9VLC5_DROME; Q9VLC5

Genbank Protein ID

AE014134; EU154389; EU154390; EU154391; EU154392; EU154393; EU154394; EU154395; EU154396; EU154397; AE014134

Genbank Nucleotide ID

AAF52769.1; ABV68992.1; ABV68993.1; ABV68994.1; ABV68995.1; ABV68996.1; ABV68997.1; ABV68998.1; ABV68999.1; ABV69000.1; AGB92825.1

Protein Name

Aldehyde dehydrogenase

Protein Synonyms/Alias

Aldehyde dehydrogenase, isoform A; Aldehyde dehydrogenase, isoform B

Gene Name

Aldh

Gene Synonyms/Alias

CG3752; Dmel_CG3752

Created Date

July 27, 2013

Organism

Drosophila melanogaster (Fruit fly)

NCBI Taxa ID

7227

Lysine Modification

Position	Peptide	Type	References
91	QAARNAFKLGSPWRR	acetylation	[1]
332	SRTFVEDKIYDEFVE	acetylation	[1]
377	EKILGMIKTGKKQGA	acetylation	[1]
458	VFTKDLDKANYIVGG	acetylation	[1]
514	EVKSVIVKVAQKNS*	acetylation	[1]

Reference

[1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702]

Functional Description

Sequence Annotation

Keyword

Complete proteome; Oxidoreductase; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

520 AA

Protein Sequence

MLRVLKTGAL LRSQAKNFAA AVANYSSLPQ PQTTPDILYT GVFINNEWHK SKSGKIFETI 60
NPTTAEVIAE IQCADKEDID IAVQAARNAF KLGSPWRRMD ASERGRLLYR LADLMERDQV 120
YLASLETLDN GKPYSMSYNV DLPTAIKNLR YFAGWADKNH GKTIPMDGDF FTYTRHEPVG 180
VCGQIIPWNF PILMMAWKLG PALATGNTIV LKPAEQTSLT ALYIAQLVKE AGFPEGVVNV 240
VPGFGTAGAA LANHCDVDKV AFTGSTDVGK LIQLASGNTN LKRVTLELGG KSPNIILSDT 300
DMDYAVETAH FGLFFNMGQC CCAGSRTFVE DKIYDEFVER SAERAKKRTV GNPFDLNTEQ 360
GPQVNEEQME KILGMIKTGK KQGAKLVAGG SRPEGLPGYF VQPTVFADVQ DDMTIAREEI 420
FGPVQQLIRF KKLDEVIERA NNSEYGLAAA VFTKDLDKAN YIVGGLRAGT VWVNTYNVLA 480
AQAPFGGYKM SGHGRENGEY ALSNYTEVKS VIVKVAQKNS 520

Gene Ontology

GO:0005811; C:lipid particle; IDA:FlyBase.
GO:0005739; C:mitochondrion; IDA:FlyBase.
GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:EC.
GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IDA:FlyBase.
GO:0045471; P:response to ethanol; IMP:FlyBase.

Interpro

IPR016161; Ald_DH/histidinol_DH.
IPR016163; Ald_DH_C.
IPR016160; Ald_DH_CS.
IPR016162; Ald_DH_N.
IPR015590; Aldehyde_DH_dom.

Pfam

PF00171; Aldedh

SMART

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS
PS00687; ALDEHYDE_DEHYDR_GLU

PRINTS