CPLM-009541

Genbank Nucleotide ID

60S ribosomal protein L23a

Protein Synonyms/Alias

Homo sapiens (Human)

Position	Peptide	Type	References
7	*MAPKAKKEAPAPPK	ubiquitination	[1]
14	KEAPAPPKAEAKAKA	ubiquitination	[1, 2]
18	APPKAEAKAKALKAK	ubiquitination	[2]
20	PKAEAKAKALKAKKA	ubiquitination	[1]
70	KSAPRRNKLDHYAII	acetylation	[3]
70	KSAPRRNKLDHYAII	ubiquitination	[1, 4]
78	LDHYAIIKFPLTTES	ubiquitination	[4, 5]
88	LTTESAMKKIEDNNT	ubiquitination	[5]
115	QIKQAVKKLYDIDVA	ubiquitination	[1, 4, 5]
123	LYDIDVAKVNTLIRP	ubiquitination	[1, 4]
152	DALDVANKIGII***	ubiquitination	[1, 5, 6, 7]

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
[3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
[4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[6] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
Xu G, Paige JS, Jaffrey SR.
Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865]
[7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

This protein binds to a specific region on the 26S rRNA (By similarity).

MOD_RES 2 2 N,N,N-trimethylalanine (By similarity).
MOD_RES 45 45 Phosphothreonine.

3D-structure; Complete proteome; Methylation; Phosphoprotein; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
GO:0008283; P:cell proliferation; IMP:UniProtKB.
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
GO:0006414; P:translational elongation; TAS:Reactome.
GO:0006413; P:translational initiation; TAS:Reactome.
GO:0006415; P:translational termination; TAS:Reactome.
GO:0019083; P:viral transcription; TAS:Reactome.

IPR012677; Nucleotide-bd_a/b_plait.
IPR019985; Ribosomal_L23.
IPR012678; Ribosomal_L23/L15e_core_dom.
IPR001014; Ribosomal_L23/L25_CS.
IPR005633; Ribosomal_L23/L25_N.
IPR013025; Ribosomal_L25/23.

PF00276; Ribosomal_L23
PF03939; Ribosomal_L23eN

PS00050; RIBOSOMAL_L23