| Tag | Content |
|---|
| CPLM ID | CPLM-015222 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrator complex subunit 5 |
Protein Synonyms/Alias | Int5 |
Gene Name | INTS5 |
Gene Synonyms/Alias | KIAA1698 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 286 | SPAIPAEKRVPKIAS | ubiquitination | [1] | | 686 | QTSPAGLKAVLQLLV | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. |
Sequence Annotation | MOD_RES 2 2 N-acetylserine.
MOD_RES 279 279 Phosphoserine. |
Keyword | Acetylation; Complete proteome; Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1019 AA |
Protein Sequence | MSALCDPPGA PGPPGPAPAT HGPAPLSAQE LSQEIKAFLT GVDPILGHQL SAREHARCGL 60
LLLRSLPPAR AAVLDHLRGV FDESVRAHLA ALDETPVAGP PHLRPPPPSH VPAGGPGLED 120
VVQEVQQVLS EFIRANPKAW APVISAWSID LMGQLSSTYS GQHQRVPHAT GALNELLQLW 180
MGCRATRTLM DIYVQCLSAL IGSCPDACVD ALLDTSVQHS PHFDWVVAHI GSSFPGTIIS 240
RVLSCGLKDF CVHGGAGGGA GSSGGSSSQT PSTDPFPGSP AIPAEKRVPK IASVVGILGH 300
LASRHGDSIR RELLRMFHDS LAGGSGGRSG DPSLQATVPF LLQLAVMSPA LLGTVSGELV 360
DCLKPPAVLS QLQQHLQGFP REELDNMLNL AVHLVSQASG AGAYRLLQFL VDTAMPASVI 420
TTQGLAVPDT VREACDRLIQ LLLLHLQKLV HHRGGSPGEG VLGPPPPPRL VPFLDALKNH 480
VGELCGETLR LERKRFLWQH QLLGLLSVYT RPSCGPEALG HLLSRARSPE ELSLATQLYA 540
GLVVSLSGLL PLAFRSCLAR VHAGTLQPPF TARFLRNLAL LVGWEQQGGE GPAALGAHFG 600
ESASAHLSDL APLLLHPEEE VAEAAASLLA ICPFPSEALS PSQLLGLVRA GVHRFFASLR 660
LHGPPGVASA CQLLTRLSQT SPAGLKAVLQ LLVEGALHRG NTELFGGQVD GDNETLSVVS 720
ASLASASLLD TNRRHTAAVP GPGGIWSVFH AGVIGRGLKP PKFVQSRNQQ EVIYNTQSLL 780
SLLVHCCSAP GGTECGECWG APILSPEAAK AVAVTLVESV CPDAAGAELA WPPEEHARAT 840
VERDLRIGRR FREQPLLFEL LKLVAAAPPA LCYCSVLLRG LLAALLGHWE ASRHPDTTHS 900
PWHLEASCTL VAVMAEGSLL PPALGNMHEV FSQLAPFEVR LLLLSVWGFL REHGPLPQKF 960
IFQSERGRFI RDFSREGGGE GGPHLAVLHS VLHRNIDRLG LFSGRFQAPS PSTLLRQGT 1019 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |