| Tag | Content |
|---|
| CPLM ID | CPLM-023527 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Prolactin regulatory element-binding protein |
Protein Synonyms/Alias | Mammalian guanine nucleotide exchange factor mSec12 |
Gene Name | Preb |
Gene Synonyms/Alias | Sec12 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 24 | YALRIDPKTGLLIAA | acetylation | [1] |
|
Reference | [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ. Mol Cell. 2013 Jan 10;49(1):186-99. [ PMID: 23201123] |
Functional Description | Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER. |
Sequence Annotation | REPEAT 152 191 WD 1.
REPEAT 194 232 WD 2.
REPEAT 298 337 WD 3.
MOD_RES 10 10 Nitrated tyrosine. |
Keyword | Activator; Complete proteome; DNA-binding; Endoplasmic reticulum; ER-Golgi transport; Membrane; Nitration; Nucleus; Protein transport; Reference proteome; Repeat; Transcription; Transcription regulation; Transmembrane; Transmembrane helix; Transport; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 417 AA |
Protein Sequence | MGRRRGVELY RAPFPLYALR IDPKTGLLIA AGGGGAAKTG IKNGVHFLQL ELINGCLSAS 60
LLHSHDTETR ATMNLALAGD ILAAGQDAQC QLLRFQVHQQ KGSKAEKSGS KEQGPRQRKG 120
APPAEKKSGA QVHPEGVELK VKNLEAVQTD FSNEPLQKVV CFNHDNTLLA TGGTDGHVRV 180
WKVPSLEKVL EFKAHEGEIG DLTLGPDGKL VTVGWDFKAS VWQKDQLVTQ LQWQENGPAS 240
SNTPYRYQAC RFGQVPDQLG GLRLFTVQIP HKRLRQPPPC YLTAWDSSTF LPLRTRSCGH 300
EVISCLSVSD SGTFLGLGTV TGSVAIYIAF SLQRLYYVKE AHGIVVTDVT FLPEKGCGPK 360
LLGPHETALF SVAVDSRCQL HLLPSRRSVP VWLLLLLCVG LIIVTILLLQ TAFPGFL 417 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:MGI. GO:0015031; P:protein transport; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. |
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