CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023249
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 26S proteasome non-ATPase regulatory subunit 13 
Protein Synonyms/Alias
 26S proteasome regulatory subunit RPN9; 26S proteasome regulatory subunit S11; 26S proteasome regulatory subunit p40.5 
Gene Name
 PSMD13 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
163RFYDLSSKYYQTIGNubiquitination[1]
176GNHASYYKDALRFLGubiquitination[1]
254VERFQTLKTAWGQQPubiquitination[1]
323ALSVGLVKGSIDEVDubiquitination[1]
349VLDLQQIKGMKDRLEubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. 
Sequence Annotation
 DOMAIN 239 335 PCI.
 MOD_RES 298 298 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Polymorphism; Proteasome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 376 AA 
Protein Sequence
MKDVPGFLQQ SQNSGPGQPA VWHRLEELYT KNFMKTLSVN LNTGKSLSSV FHFENECIDA 60
RRCSKAGGFY FRVNPLSLVE IILHVVRQMT DPNVALTFLE KTREKVKSSD EAVILCKTAI 120
GALKLNIGDL QVTKETIEDV EEMLNNLPGV TSVHSRFYDL SSKYYQTIGN HASYYKDALR 180
FLGCVDIKDL PVSEQQERAF TLGLAGLLGE GVFNFGELLM HPVLESLRNT DRQWLIDTLY 240
AFNSGNVERF QTLKTAWGQQ PDLAANEAQL LRKIQLLCLM EMTFTRPANH RQLTFEEIAK 300
SAKITVNEVE LLVMKALSVG LVKGSIDEVD KRVHMTWVQP RVLDLQQIKG MKDRLEFWCT 360
DVKSMEMLVE HQAHDILT 378 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005838; C:proteasome regulatory particle; TAS:ProtInc.
 GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.
 GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
 GO:0006915; P:apoptotic process; TAS:Reactome.
 GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome.
 GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome.
 GO:0010467; P:gene expression; TAS:Reactome.
 GO:0007127; P:meiosis I; IEA:Compara.
 GO:0016071; P:mRNA metabolic process; TAS:Reactome.
 GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0000209; P:protein polyubiquitination; TAS:Reactome.
 GO:0042981; P:regulation of apoptotic process; TAS:Reactome.
 GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0016032; P:viral reproduction; TAS:Reactome. 
Interpro
 IPR000717; PCI_dom. 
Pfam
 PF01399; PCI 
SMART
 SM00088; PINT 
PROSITE
  
PRINTS