UniProt Accession

 MBRL_HUMAN; Q4ZIN3; O60392; Q8NF79; Q96H30 

Genbank Protein ID

 DQ005958; AC004528; BC008957; AK090400 

Genbank Nucleotide ID

 AAY27747.1; AAC12681.1; AAH08957.1; BAC03381.1 

Protein Name

 Membralin 

Protein Synonyms/Alias

 Transmembrane protein 259 

Gene Name

 TMEM259 

Gene Synonyms/Alias

 C19orf6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
280	LAENEENKGFLRNVV	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

 CARBOHYD 189 189 N-linked (GlcNAc...).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Glycoprotein; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 620 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 

Interpro

 IPR019144; Membralin. 

Pfam

 PF09746; Membralin 

SMART

  

PROSITE

  

PRINTS