CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037027
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Claspin 
Protein Synonyms/Alias
  
Gene Name
 CLSPN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
105TKIKRIYKTVADSDEubiquitination[1]
412EELEIQEKQKQSDIRubiquitination[1]
507LGVDVSIKPRLGADEubiquitination[1]
606AKLQEAMKLRRFEERacetylation[2]
838RNQYQALKPRLPLASubiquitination[1]
872KFTSQAEKHLPRKSDacetylation[2, 3]
910PASSELNKQEKESSMubiquitination[4]
1212QPKAVLQKLAALSDHubiquitination[1]
1268SPSPKHLKTDDSTSGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1286 AA 
Protein Sequence
MTGEVGSEVH LEINDPNVIS QEEADSPSDS GQGSYETIGP LSEGDSDEEI FVSKKLKNRK 60
VLQDSDSETE DTNASPEKTT YDSAEEENKE NLYAGKNTKI KRIYKTVADS DESYMEKSLY 120
QENLEAQVKP CLELSLQSGN STDFTTDRKS SKKHIHDKEG TAGKAKVKSK RRLEKEERKM 180
EKIRQLKKKE TKNQEDDVEQ PFNDSGCLLV DKDLFETGLE DENNSPLEDE ESLESIRAAV 240
KNKVKKHKKK EPSLESGVHS FEEGSELSKG TTRKERKAAR LSKEALKQLH SETQRLIRES 300
ALNLPYHMPE NKTIHDFFKR KPRPTCHGNA MALLKSSKYQ SSHHKEIIDT ANTTEMNSDH 360
HSKGSEQTTG AENEVETNAL PVVSKETQII TGSDESCRKD LVKNEELEIQ EKQKQSDIRP 420
SPGDSSVLQQ ESNFLGNNHS EECQVGGLVA FEPHALEGEG PQNPEETDEK VEEPEQQNKS 480
SAVGPPEKVR RFTLDRLKQL GVDVSIKPRL GADEDSFVIL EPETNRELEA LKQRFWKHAN 540
PAAKPRAGQT VNVNVIVKDM GTDGKEELKA DVVPVTLAPK KLDGASHTKP GEKLQVLKAK 600
LQEAMKLRRF EERQKRQALF KLDNEDGFEE EEEEEEEMTD ESEEDGEEKV EKEEKEEELE 660
EEEEKEEEEE EEGNQEDSSS KMGYFPTEEK SETDENSGKQ PSKLDEDDSC SLLTKESSHN 720
SSFELIGSTI PSYQPCNRQT GRGTSFFPTA GGFRSPSPGL FRASLVSSAS KSSGKLSEPS 780
LPIEDSQDLY NASPEPKTLF LGAGDFQFCL EDDTQSQLLD ADGFLNVRNH RNQYQALKPR 840
LPLASMDENA MDANMDELLD LCTGKFTSQA EKHLPRKSDK KENMEELLNL CSGKFTSQDA 900
STPASSELNK QEKESSMGDP MEEALALCSG SFPTDKEEED EEEEFGDFRL VSNDNEFDSD 960
EDEHSDSGND LALEDHEDDD EEELLKRSEK LKRQMRLRKY LEDEAEVSGS DVGSEDEYDG 1020
EEIDEYEEDV IDEVLPSDEE LQSQIKKIHM KTMLDDDKRQ LRLYQERYLA DGDLHSDGPG 1080
RMRKFRWKNI DDASQMDLFH RDSDDDQTEE QLDESEARWR KERIEREQWL RDMAQQGKIT 1140
AEEEEEIGED SQFMILAKKV TAKALQKNAS RPMVIQESKS LLRNPFEAIR PGSAQQVKTG 1200
SLLNQPKAVL QKLAALSDHN PSAPRNSRNF VFHTLSPVKA EAAKESSKSQ VKKRGPSFMT 1260
SPSPKHLKTD DSTSGLTRSI FKYLES 1286 
Gene Ontology
  
Interpro
 IPR024147; Claspin.
 IPR024146; Claspin/Claspin-like. 
Pfam
  
SMART
  
PROSITE
  
PRINTS